DegronMD - Q5TEJ8(THEMIS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G601S	TCGA-A5-A1OF	UCEC	TCGA	DGSSTYSKIP	CBL_PTK	600:609	Mutation altering degron motif	0.5882
p.P609S	TCGA-AJ-A5DW	UCEC	TCGA	DGSSTYSKIP	CBL_PTK	600:609	Mutation altering degron motif	0.6752
p.A618T	TCGA-CN-A498	HNSC	TCGA	DGSSTYSKIP	CBL_PTK	600:609	Mutation rewiring degron network	0.0833
p.A618T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DGSSTYSKIP	CBL_PTK	600:609	Mutation rewiring degron network	0.0833
p.A618T	ACH-000981	Leukemia	CCLE	DGSSTYSKIP	CBL_PTK	600:609	Mutation rewiring degron network	0.0833
p.A618T	DND-41	haematopoietic and lymphoid tissue	COSMIC	DGSSTYSKIP	CBL_PTK	600:609	Mutation rewiring degron network	0.0833
p.K590N	TCGA-EE-A29E	SKCM	TCGA	DGSSTYSKIP	CBL_PTK	600:609	Mutation substituting flanking lysine	0.1667
p.K607N	TCGA-XF-AAMX	BLCA	TCGA	DGSSTYSKIP	CBL_PTK	600:609	Mutation altering degron motif	0.5806
p.R616M	SIDM02041	Colorectal Carcinoma	GDSC	DGSSTYSKIP	CBL_PTK	600:609	Mutation rewiring degron network	0.1389
p.R612G	SIDM00232	Kidney Carcinoma	GDSC	DGSSTYSKIP	CBL_PTK	600:609	Mutation rewiring degron network	0.25
p.R612G	SIDM01729	Endometrial Carcinoma	GDSC	DGSSTYSKIP	CBL_PTK	600:609	Mutation rewiring degron network	0.25
p.R612G	NCC021	kidney	COSMIC	DGSSTYSKIP	CBL_PTK	600:609	Mutation rewiring degron network	0.25
p.A591V	SIDM00576	Acute Myeloid Leukemia	GDSC	DGSSTYSKIP	CBL_PTK	600:609	Mutation rewiring degron network	0.0833
p.A591V	ACH-002290	Leukemia	CCLE	DGSSTYSKIP	CBL_PTK	600:609	Mutation rewiring degron network	0.0833
p.A591V	NKM-1	haematopoietic and lymphoid tissue	COSMIC	DGSSTYSKIP	CBL_PTK	600:609	Mutation rewiring degron network	0.0833

Kaplan plot for THEMIS2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

THEMIS2

UniProt ID: Q5TEJ8

Entrez ID: 9473

Protein name: Protein THEMIS2 (Induced by contact to basement membrane 1 protein) (Protein ICB-1) (Thymocyte-expressed molecule involved in selection protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for THEMIS2 in