DegronMD

Uniprot ID: Q5TEJ8

Source protein: Protein THEMIS2

Source gene: THEMIS2

Class: CBL_PTK

Location: 600:609

E3 ligase: CBL

DEGRON score: 0.998

ASA_SCORE: 78.52

COIL: 0.8913

CONS_SCORE: 0.5683

DSS_SCORE: 0.6012

HELIX: 0.032

FCONS_SCORE: 1.19

RIG_SCORE: 0.6306

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G601S	TCGA-A5-A1OF	UCEC	TCGA	DGSSTYSKIP	CBL_PTK	0.5882
p.P609S	TCGA-AJ-A5DW	UCEC	TCGA	DGSSTYSKIP	CBL_PTK	0.6752
p.A618T	TCGA-CN-A498	HNSC	TCGA	DGSSTYSKIP	CBL_PTK	0.0833
p.A618T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DGSSTYSKIP	CBL_PTK	0.0833
p.A618T	ACH-000981	Leukemia	CCLE	DGSSTYSKIP	CBL_PTK	0.0833
p.A618T	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	DGSSTYSKIP	CBL_PTK	0.0833
p.K590N	TCGA-EE-A29E	SKCM	TCGA	DGSSTYSKIP	CBL_PTK	0.1667
p.K607N	TCGA-XF-AAMX	BLCA	TCGA	DGSSTYSKIP	CBL_PTK	0.5806
p.R616M	SIDM02041	Colorectal Carcinoma	GDSC	DGSSTYSKIP	CBL_PTK	0.1389
p.R612G	SIDM00232	Kidney Carcinoma	GDSC	DGSSTYSKIP	CBL_PTK	0.25
p.R612G	SIDM01729	Endometrial Carcinoma	GDSC	DGSSTYSKIP	CBL_PTK	0.25
p.R612G	NCC021	kidney	COSMIC	DGSSTYSKIP	CBL_PTK	0.25
p.A591V	SIDM00576	Acute Myeloid Leukemia	GDSC	DGSSTYSKIP	CBL_PTK	0.0833
p.A591V	ACH-002290	Leukemia	CCLE	DGSSTYSKIP	CBL_PTK	0.0833
p.A591V	NKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	DGSSTYSKIP	CBL_PTK	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TEJ8	Protein THEMIS2	CBL_PTK	600:609	DGSSTYSKIP	CBL	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons