DegronMD - Q5TGY1(TMCO4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R178Q	TCGA-05-4389	LUAD	TCGA	KRYLLIGLA	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.0556
p.R178Q	DO24307	LUAD	ICGC	KRYLLIGLA	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.0556
p.R178Q	DO232635	PBCA	ICGC	KRYLLIGLA	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.0556
p.R178Q	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	KRYLLIGLA	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.0556
p.R178Q	ACH-000925	Lung Cancer	CCLE	KRYLLIGLA	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.0556
p.L195M	TCGA-AP-A1DK	UCEC	TCGA	KRYLLIGLA	DEG_APCC_DBOX_1	188:196	Mutation altering degron motif	0.5999
p.L195M	DO42033	UCEC	ICGC	KRYLLIGLA	DEG_APCC_DBOX_1	188:196	Mutation altering degron motif	0.5999
p.R184W	TCGA-F4-6463	COAD	TCGA	KRYLLIGLA	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.2222
p.R184W	DO7958	COAD	ICGC	KRYLLIGLA	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.2222
p.R184W	SIDM00529	Breast Carcinoma	GDSC	KRYLLIGLA	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.2222
p.R184W	SIDM00431	T-Lymphoblastic Leukemia	GDSC	KRYLLIGLA	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.2222
p.R184W	SIDM01318	Hepatocellular Carcinoma	GDSC	KRYLLIGLA	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.2222
p.T202M	TCGA-KK-A6E8	PRAD	TCGA	KRYLLIGLA	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.1667
p.T202M	TCGA-LA-A7SW	LUSC	TCGA	KRYLLIGLA	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.1667
p.T202M	DO52024	LUSC	ICGC	KRYLLIGLA	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.1667
p.T202M	DO51364	PRAD	ICGC	KRYLLIGLA	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.1667
p.R189H	DO230335	COCA	ICGC	KRYLLIGLA	DEG_APCC_DBOX_1	188:196	Mutation altering degron motif	0.8244
p.G205D	DO233088	GACA	ICGC	KRYLLIGLA	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.0833
p.L191F	DO220857	MELA	ICGC	KRYLLIGLA	DEG_APCC_DBOX_1	188:196	Mutation altering degron motif	0.587

Kaplan plot for TMCO4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMCO4

UniProt ID: Q5TGY1

Entrez ID: 255104

Protein name: Transmembrane and coiled-coil domain-containing protein 4

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMCO4 in