DegronMD

Uniprot ID: Q5TGY1

Source protein: Transmembrane and coiled-coil domain-containing protein 4

Source gene: TMCO4

Class: DEG_APCC_DBOX_1

Location: 188:196

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8088

ASA_SCORE: 74.5333

COIL: 0.3497

CONS_SCORE: 0.5446

DSS_SCORE: 0.1108

HELIX: 0.5372

FCONS_SCORE: 1.1886

RIG_SCORE: 0.906

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R178Q	TCGA-05-4389	LUAD	TCGA	KRYLLIGLA	DEG_APCC_DBOX_1	0.0556
p.R178Q	DO24307	LUAD	ICGC	KRYLLIGLA	DEG_APCC_DBOX_1	0.0556
p.R178Q	DO232635	PBCA	ICGC	KRYLLIGLA	DEG_APCC_DBOX_1	0.0556
p.R178Q	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	KRYLLIGLA	DEG_APCC_DBOX_1	0.0556
p.R178Q	ACH-000925	Lung Cancer	CCLE	KRYLLIGLA	DEG_APCC_DBOX_1	0.0556
p.L195M	TCGA-AP-A1DK	UCEC	TCGA	KRYLLIGLA	DEG_APCC_DBOX_1	0.5999
p.L195M	DO42033	UCEC	ICGC	KRYLLIGLA	DEG_APCC_DBOX_1	0.5999
p.R184W	TCGA-F4-6463	COAD	TCGA	KRYLLIGLA	DEG_APCC_DBOX_1	0.2222
p.R184W	DO7958	COAD	ICGC	KRYLLIGLA	DEG_APCC_DBOX_1	0.2222
p.R184W	SIDM00529	Breast Carcinoma	GDSC	KRYLLIGLA	DEG_APCC_DBOX_1	0.2222
p.R184W	SIDM00431	T-Lymphoblastic Leukemia	GDSC	KRYLLIGLA	DEG_APCC_DBOX_1	0.2222
p.R184W	SIDM01318	Hepatocellular Carcinoma	GDSC	KRYLLIGLA	DEG_APCC_DBOX_1	0.2222
p.T202M	TCGA-KK-A6E8	PRAD	TCGA	KRYLLIGLA	DEG_APCC_DBOX_1	0.1667
p.T202M	TCGA-LA-A7SW	LUSC	TCGA	KRYLLIGLA	DEG_APCC_DBOX_1	0.1667
p.T202M	DO52024	LUSC	ICGC	KRYLLIGLA	DEG_APCC_DBOX_1	0.1667
p.T202M	DO51364	PRAD	ICGC	KRYLLIGLA	DEG_APCC_DBOX_1	0.1667
p.R189H	DO230335	COCA	ICGC	KRYLLIGLA	DEG_APCC_DBOX_1	0.8244
p.G205D	DO233088	GACA	ICGC	KRYLLIGLA	DEG_APCC_DBOX_1	0.0833
p.L191F	DO220857	MELA	ICGC	KRYLLIGLA	DEG_APCC_DBOX_1	0.587

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TGY1	Transmembrane and coiled-coil domain-containing protein 4	DEG_APCC_DBOX_1	188:196	KRYLLIGLA	APC,CDC20,FZR1	0.8088	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons