DegronMD - Q5TKA1(LIN9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K59N	TCGA-73-4670	LUAD	TCGA	RSRLFSD	LIG_APCC_ABBAyCdc20_2	60:66	Mutation rewiring degron network	0.3056
p.R76Q	TCGA-BR-8361	STAD	TCGA	RSRLFSD	LIG_APCC_ABBAyCdc20_2	60:66	Mutation blocking phosphorylation signal	0.5
p.R76Q	TCGA-FI-A2D5	UCEC	TCGA	RSRLFSD	LIG_APCC_ABBAyCdc20_2	60:66	Mutation blocking phosphorylation signal	0.5
p.R76Q	DO48032	STAD	ICGC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	60:66	Mutation blocking phosphorylation signal	0.5
p.R76Q	DO41331	UCEC	ICGC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	60:66	Mutation blocking phosphorylation signal	0.5
p.R76Q	SIDM02078	Pancreatic Carcinoma	GDSC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	60:66	Mutation blocking phosphorylation signal	0.5
p.R76Q	SIDM00193	Colorectal Carcinoma	GDSC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	60:66	Mutation blocking phosphorylation signal	0.5
p.R76Q	ACH-000991	Colon/Colorectal Cancer	CCLE	RSRLFSD	LIG_APCC_ABBAyCdc20_2	60:66	Mutation blocking phosphorylation signal	0.5
p.R76Q	SNU-81	large intestine	COSMIC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	60:66	Mutation blocking phosphorylation signal	0.5
p.E68A	TCGA-CV-A6JE	HNSC	TCGA	RSRLFSD	LIG_APCC_ABBAyCdc20_2	60:66	Mutation rewiring degron network	0.2778
p.P70L	TCGA-Z2-A8RT	SKCM	TCGA	RSRLFSD	LIG_APCC_ABBAyCdc20_2	60:66	Mutation rewiring degron network	0.2222
p.P70L	DO51301	SKCM	ICGC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	60:66	Mutation rewiring degron network	0.2222
p.T56R	DO50045	BRCA	ICGC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	60:66	Mutation rewiring degron network	0.2222
p.R75C	DO234208	ESAD	ICGC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	60:66	Mutation rewiring degron network	0.0833
p.R75C	DO27453	LUSC	ICGC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	60:66	Mutation rewiring degron network	0.0833
p.R75G	DO233169	GACA	ICGC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	60:66	Mutation rewiring degron network	0.0833
p.E52A	DO49046	HNSC	ICGC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	60:66	Mutation rewiring degron network	0.1111
p.T56I	DO228422	LICA	ICGC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	60:66	Mutation rewiring degron network	0.2222
p.R75H	DO45101	LIRI	ICGC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	60:66	Mutation rewiring degron network	0.0833
p.R75H	DO50666	ORCA	ICGC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	60:66	Mutation rewiring degron network	0.0833
p.K75N	SIDM00482	Chronic Myelogenous Leukemia	GDSC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	60:66	Mutation rewiring degron network	0.0833
p.K75N	ACH-002302	Leukemia	CCLE	RSRLFSD	LIG_APCC_ABBAyCdc20_2	60:66	Mutation rewiring degron network	0.0833
p.K75N	RPMI-8866	haematopoietic and lymphoid tissue	COSMIC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	60:66	Mutation rewiring degron network	0.0833

Kaplan plot for LIN9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LIN9

UniProt ID: Q5TKA1

Entrez ID: 286826

Protein name: Protein lin-9 homolog (HuLin-9) (hLin-9) (Beta subunit-associated regulator of apoptosis) (TUDOR gene similar protein) (Type I interferon receptor beta chain-associated protein) (pRB-associated protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LIN9 in