DegronMD

Uniprot ID: Q5TKA1

Source protein: Protein lin-9 homolog

Source gene: LIN9

Class: LIG_APCC_ABBAyCdc20_2

Location: 60:66

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9528

ASA_SCORE: 95.0286

COIL: 0.679

CONS_SCORE: 0.4849

DSS_SCORE: 0.5804

HELIX: 0.2714

FCONS_SCORE: 1.1694

RIG_SCORE: 0.6987

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K59N	TCGA-73-4670	LUAD	TCGA	RSRLFSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R76Q	TCGA-BR-8361	STAD	TCGA	RSRLFSD	LIG_APCC_ABBAyCdc20_2	0.5
p.R76Q	TCGA-FI-A2D5	UCEC	TCGA	RSRLFSD	LIG_APCC_ABBAyCdc20_2	0.5
p.R76Q	DO48032	STAD	ICGC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	0.5
p.R76Q	DO41331	UCEC	ICGC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	0.5
p.R76Q	SIDM02078	Pancreatic Carcinoma	GDSC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	0.5
p.R76Q	SIDM00193	Colorectal Carcinoma	GDSC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	0.5
p.R76Q	ACH-000991	Colon/Colorectal Cancer	CCLE	RSRLFSD	LIG_APCC_ABBAyCdc20_2	0.5
p.R76Q	SNU-81	large_intestine	COSMIC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	0.5
p.E68A	TCGA-CV-A6JE	HNSC	TCGA	RSRLFSD	LIG_APCC_ABBAyCdc20_2	0.2778
p.P70L	TCGA-Z2-A8RT	SKCM	TCGA	RSRLFSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.P70L	DO51301	SKCM	ICGC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.T56R	DO50045	BRCA	ICGC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R75C	DO234208	ESAD	ICGC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R75C	DO27453	LUSC	ICGC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R75G	DO233169	GACA	ICGC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.E52A	DO49046	HNSC	ICGC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T56I	DO228422	LICA	ICGC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R75H	DO45101	LIRI	ICGC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R75H	DO50666	ORCA	ICGC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.K75N	SIDM00482	Chronic Myelogenous Leukemia	GDSC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.K75N	ACH-002302	Leukemia	CCLE	RSRLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.K75N	RPMI-8866	haematopoietic_and_lymphoid_tissue	COSMIC	RSRLFSD	LIG_APCC_ABBAyCdc20_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TKA1	Protein lin-9 homolog	LIG_APCC_ABBAyCdc20_2	60:66	RSRLFSD	APC,CDC20,FZR1	0.9528	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons