DegronMD - Q5VSL9(STRIP1)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E64D	TCGA-IB-7651	PAAD	TCGA	DSEGYSESP	CBL_PTK	58:66	Mutation altering degron motif	0.5647
p.E64D	DO46657	PAAD	ICGC	DSEGYSESP	CBL_PTK	58:66	Mutation altering degron motif	0.5647
p.K57Q	DO233200	GACA	ICGC	DSEGYSESP	CBL_PTK	58:66	Mutation blocking ubiquitination signal	0.75
p.A50S	DO229035	LICA	ICGC	DSEGYSESP	CBL_PTK	58:66	Mutation rewiring degron network	0.1111
p.A48S	DO229180	THCA	ICGC	DSEGYSESP	CBL_PTK	58:66	Mutation rewiring degron network	0.0556
p.A48S	ACH-000345	Neuroblastoma	CCLE	DSEGYSESP	CBL_PTK	58:66	Mutation rewiring degron network	0.0556
p.S63L	SIDM00195	Ewing's Sarcoma	GDSC	DSEGYSESP	CBL_PTK	58:66	Mutation altering degron motif	0.8778
p.S63L	ACH-002117	Bone Cancer	CCLE	DSEGYSESP	CBL_PTK	58:66	Mutation altering degron motif	0.8778
p.S63L	EW-24	bone	COSMIC	DSEGYSESP	CBL_PTK	58:66	Mutation altering degron motif	0.8778
p.R53H	ACH-000978	Endometrial/Uterine Cancer	CCLE	DSEGYSESP	CBL_PTK	58:66	Mutation rewiring degron network	0.1944
p.R51L	NCI-H661	lung	COSMIC	DSEGYSESP	CBL_PTK	58:66	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons