DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DSEGYSESP
Uniprot ID:
Q5VSL9
Source protein:
Striatin-interacting protein 1
Source gene:
STRIP1
Class:
CBL_PTK
Location:
58:66
E3 ligase:
CBL
DEGRON score:
0.9921
ASA_SCORE:
87.2
COIL:
0.9093
CONS_SCORE:
0.3109
DSS_SCORE:
0.5986
HELIX:
0.05
FCONS_SCORE:
0.8706
RIG_SCORE:
0.6472
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E64D
TCGA-IB-7651
PAAD
TCGA
DSEGYSESP
CBL_PTK
0.5647
p.E64D
DO46657
PAAD
ICGC
DSEGYSESP
CBL_PTK
0.5647
p.K57Q
DO233200
GACA
ICGC
DSEGYSESP
CBL_PTK
0.75
p.A50S
DO229035
LICA
ICGC
DSEGYSESP
CBL_PTK
0.1111
p.A48S
DO229180
THCA
ICGC
DSEGYSESP
CBL_PTK
0.0556
p.A48S
ACH-000345
Neuroblastoma
CCLE
DSEGYSESP
CBL_PTK
0.0556
p.S63L
SIDM00195
Ewing's Sarcoma
GDSC
DSEGYSESP
CBL_PTK
0.8778
p.S63L
ACH-002117
Bone Cancer
CCLE
DSEGYSESP
CBL_PTK
0.8778
p.S63L
EW-24
bone
COSMIC
DSEGYSESP
CBL_PTK
0.8778
p.R53H
ACH-000978
Endometrial/Uterine Cancer
CCLE
DSEGYSESP
CBL_PTK
0.1944
p.R51L
NCI-H661
lung
COSMIC
DSEGYSESP
CBL_PTK
0.1389
Drug responses associated with STRIP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSEGYSESP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5VSL9
Striatin-interacting protein 1
CBL_PTK
58:66
DSEGYSESP
CBL
0.9921
More...
