DegronMD - Q5VT25(CDC42BPA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A639D	TCGA-39-5030	LUSC	TCGA	LEVHTE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.25
p.K644E	TCGA-55-6985	LUAD	TCGA	LEVHTE	LIG_APCC_ABBA_1	631:636	Mutation substituting flanking lysine	0.2222
p.R646M	TCGA-69-7979	LUAD	TCGA	LEVHTE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.0556
p.R622C	TCGA-DU-6392	LGG	TCGA	LEVHTE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.0833
p.R622C	DO22237	LGG	ICGC	LEVHTE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.0833
p.E633K	DO6254	CESC	ICGC	LEVHTE	LIG_APCC_ABBA_1	631:636	Mutation altering degron motif	0.7022
p.R626I	DO222762	COCA	ICGC	LEVHTE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.1944
p.K638M	DO219174	LUSC	ICGC	LEVHTE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.2778
p.K638N	DO42312	UCEC	ICGC	LEVHTE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.2778
p.K635N	DO41572	UCEC	ICGC	LEVHTE	LIG_APCC_ABBA_1	631:636	Mutation altering degron motif	0.6918
p.E627D	DO42745	UCEC	ICGC	LEVHTE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.2222
p.A642T	SIDM00596	Endometrial Carcinoma	GDSC	LEVHTE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.1667
p.A642T	ACH-001517	Endometrial/Uterine Cancer	CCLE	LEVHTE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.1667
p.A642T	HEC-1	endometrium	COSMIC	LEVHTE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.1667
p.R622H	ACH-000954	Endometrial/Uterine Cancer	CCLE	LEVHTE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.0833
p.R637K	TE-9	oesophagus	COSMIC	LEVHTE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.3056

Kaplan plot for CDC42BPA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDC42BPA

UniProt ID: Q5VT25

Entrez ID: 8476

Protein name: Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDC42BPA in