DegronMD

Uniprot ID: Q5VT25

Source protein: Serine/threonine-protein kinase MRCK alpha

Source gene: CDC42BPA

Class: LIG_APCC_ABBA_1

Location: 631:636

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5671

ASA_SCORE: 102.7667

COIL: 0.1988

CONS_SCORE: 0.4498

DSS_SCORE: 0.4738

HELIX: 0.8035

FCONS_SCORE: 1.0717

RIG_SCORE: 0.7695

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A639D	TCGA-39-5030	LUSC	TCGA	LEVHTE	LIG_APCC_ABBA_1	0.25
p.K644E	TCGA-55-6985	LUAD	TCGA	LEVHTE	LIG_APCC_ABBA_1	0.2222
p.R646M	TCGA-69-7979	LUAD	TCGA	LEVHTE	LIG_APCC_ABBA_1	0.0556
p.R622C	TCGA-DU-6392	LGG	TCGA	LEVHTE	LIG_APCC_ABBA_1	0.0833
p.R622C	DO22237	LGG	ICGC	LEVHTE	LIG_APCC_ABBA_1	0.0833
p.E633K	DO6254	CESC	ICGC	LEVHTE	LIG_APCC_ABBA_1	0.7022
p.R626I	DO222762	COCA	ICGC	LEVHTE	LIG_APCC_ABBA_1	0.1944
p.K638M	DO219174	LUSC	ICGC	LEVHTE	LIG_APCC_ABBA_1	0.2778
p.K638N	DO42312	UCEC	ICGC	LEVHTE	LIG_APCC_ABBA_1	0.2778
p.K635N	DO41572	UCEC	ICGC	LEVHTE	LIG_APCC_ABBA_1	0.6918
p.E627D	DO42745	UCEC	ICGC	LEVHTE	LIG_APCC_ABBA_1	0.2222
p.A642T	SIDM00596	Endometrial Carcinoma	GDSC	LEVHTE	LIG_APCC_ABBA_1	0.1667
p.A642T	ACH-001517	Endometrial/Uterine Cancer	CCLE	LEVHTE	LIG_APCC_ABBA_1	0.1667
p.A642T	HEC-1	endometrium	COSMIC	LEVHTE	LIG_APCC_ABBA_1	0.1667
p.R622H	ACH-000954	Endometrial/Uterine Cancer	CCLE	LEVHTE	LIG_APCC_ABBA_1	0.0833
p.R637K	TE-9	oesophagus	COSMIC	LEVHTE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VT25	Serine/threonine-protein kinase MRCK alpha	LIG_APCC_ABBA_1	631:636	LEVHTE	APC,CDC20,FZR1	0.5671	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons