DegronMD - Q5VT97(SYDE2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.C566Y	TCGA-A5-A0G2	UCEC	TCGA	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.2222
p.C566Y	DO41235	UCEC	ICGC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.2222
p.E568G	TCGA-AA-A010	COAD	TCGA	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.1667
p.V545I	DO228483	BRCA	ICGC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	DO229005	COCA	ICGC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	DO229047	LICA	ICGC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	DO48577	PRAD	ICGC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM00588	Oral Cavity Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM00321	Ovarian Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM00866	Breast Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM00425	Ovarian Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM00371	Pancreatic Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM01040	Ovarian Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM00157	Neuroblastoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM01005	Acute Myeloid Leukemia	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM00193	Colorectal Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM01144	Gastric Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM00057	Neuroblastoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM00589	Oral Cavity Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM00552	Rhabdomyosarcoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM00040	Gastric Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM00599	Osteosarcoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM00868	Non-Cancerous	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM00997	Thyroid Gland Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM01019	Acute Myeloid Leukemia	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM00280	Gastric Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM01187	Breast Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM00045	Gastric Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM00274	Gastric Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM01018	Hodgkin's Lymphoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM01460	Glioma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM00169	Head and Neck Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM01660	Kidney Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM01368	Gastric Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM01575	Plasma Cell Myeloma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM01559	Melanoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM01694	B-Lymphoblastic Leukemia	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM01451	Pancreatic Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM01391	Neuroblastoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V545I	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.0556
p.V569I	DO229010	COCA	ICGC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.1389
p.V569I	DO229013	COCA	ICGC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.1389
p.V569I	DO229016	COCA	ICGC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.1389
p.V569I	DO229003	COCA	ICGC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.1389
p.V569I	DO229005	COCA	ICGC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.1389
p.R567Q	SIDM01149	Small Cell Lung Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation rewiring degron network	0.1944
p.N557H	SIDM00118	Colorectal Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation altering degron motif	0.6312
p.N557H	ACH-001081	Colon/Colorectal Cancer	CCLE	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation altering degron motif	0.6312
p.N557H	HCC2998	large intestine	COSMIC	PDNTPSLS	DEG_SCF_FBW7_1	555:562	Mutation altering degron motif	0.6312

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYDE2

UniProt ID: Q5VT97

Entrez ID: 84144

Protein name: Rho GTPase-activating protein SYDE2 (Synapse defective protein 1 homolog 2) (Protein syd-1 homolog 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYDE2 in