DegronMD

Uniprot ID: Q5VT97

Source protein: Rho GTPase-activating protein SYDE2

Source gene: SYDE2

Class: DEG_SCF_FBW7_1

Location: 555:562

E3 ligase: FBXW7

DEGRON score: 0.9709

ASA_SCORE: 87.3

COIL: 0.8658

CONS_SCORE: 0.3755

DSS_SCORE: 0.4161

HELIX: 0.1188

FCONS_SCORE: 1.0668

RIG_SCORE: 0.6943

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C566Y	TCGA-A5-A0G2	UCEC	TCGA	PDNTPSLS	DEG_SCF_FBW7_1	0.2222
p.C566Y	DO41235	UCEC	ICGC	PDNTPSLS	DEG_SCF_FBW7_1	0.2222
p.E568G	TCGA-AA-A010	COAD	TCGA	PDNTPSLS	DEG_SCF_FBW7_1	0.1667
p.V545I	DO228483	BRCA	ICGC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	DO229005	COCA	ICGC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	DO229047	LICA	ICGC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	DO48577	PRAD	ICGC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM00588	Oral Cavity Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM00321	Ovarian Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM00866	Breast Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM00425	Ovarian Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM00371	Pancreatic Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM01040	Ovarian Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM00157	Neuroblastoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM01005	Acute Myeloid Leukemia	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM00193	Colorectal Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM01144	Gastric Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM00057	Neuroblastoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM00589	Oral Cavity Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM00552	Rhabdomyosarcoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM00040	Gastric Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM00599	Osteosarcoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM00868	Non-Cancerous	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM00997	Thyroid Gland Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM01019	Acute Myeloid Leukemia	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM00280	Gastric Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM01187	Breast Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM00045	Gastric Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM00274	Gastric Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM01018	Hodgkin's Lymphoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM01460	Glioma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM00169	Head and Neck Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM01660	Kidney Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM01368	Gastric Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM01575	Plasma Cell Myeloma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM01559	Melanoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM01694	B-Lymphoblastic Leukemia	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM01451	Pancreatic Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM01391	Neuroblastoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V545I	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.0556
p.V569I	DO229010	COCA	ICGC	PDNTPSLS	DEG_SCF_FBW7_1	0.1389
p.V569I	DO229013	COCA	ICGC	PDNTPSLS	DEG_SCF_FBW7_1	0.1389
p.V569I	DO229016	COCA	ICGC	PDNTPSLS	DEG_SCF_FBW7_1	0.1389
p.V569I	DO229003	COCA	ICGC	PDNTPSLS	DEG_SCF_FBW7_1	0.1389
p.V569I	DO229005	COCA	ICGC	PDNTPSLS	DEG_SCF_FBW7_1	0.1389
p.R567Q	SIDM01149	Small Cell Lung Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.1944
p.N557H	SIDM00118	Colorectal Carcinoma	GDSC	PDNTPSLS	DEG_SCF_FBW7_1	0.6312
p.N557H	ACH-001081	Colon/Colorectal Cancer	CCLE	PDNTPSLS	DEG_SCF_FBW7_1	0.6312
p.N557H	HCC2998	large_intestine	COSMIC	PDNTPSLS	DEG_SCF_FBW7_1	0.6312

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PDNTPSLS

Degron related mutations and impact score

Drug responses associated with SYDE2 mutations

All proteins holding degron of PDNTPSLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VT97	Rho GTPase-activating protein SYDE2	DEG_SCF_FBW7_1	555:562	PDNTPSLS	FBXW7	0.9709	More...