DegronMD - Q5VUG0(SFMBT2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R741L	TCGA-51-6867	LUSC	TCGA	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.2222
p.R741L	DO26477	LUSC	ICGC	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.2222
p.R758Q	TCGA-AG-3574	READ	TCGA	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.25
p.R758Q	TCGA-EY-A1GV	UCEC	TCGA	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.25
p.R758Q	DO222542	MELA	ICGC	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.25
p.R758Q	DO37267	READ	ICGC	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.25
p.R758Q	DO42785	UCEC	ICGC	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.25
p.R758Q	SIDM00933	Breast Carcinoma	GDSC	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.25
p.V761I	TCGA-BG-A221	UCEC	TCGA	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.1667
p.V761I	DO42384	UCEC	ICGC	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.1667
p.R741Q	TCGA-CS-4944	LGG	TCGA	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.2222
p.R741Q	DO22512	LGG	ICGC	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.2222
p.R741Q	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.2222
p.R741Q	ACH-000843	Lung Cancer	CCLE	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.2222
p.R741Q	ACH-001648	Prostate Cancer	CCLE	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.2222
p.R741Q	HARA	lung	COSMIC	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.2222
p.A750V	TCGA-D1-A103	UCEC	TCGA	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation altering degron motif	0.5825
p.A750V	TCGA-TQ-A7RJ	LGG	TCGA	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation altering degron motif	0.5825
p.A750V	DO219853	LGG	ICGC	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation altering degron motif	0.5825
p.A750V	DO42312	UCEC	ICGC	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation altering degron motif	0.5825
p.S748L	TCGA-N5-A4RJ	UCS	TCGA	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation altering degron motif	0.6556
p.V761A	TCGA-UB-A7MB	LIHC	TCGA	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.1667
p.V761A	DO52318	LIHC	ICGC	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.1667
p.T747N	DO225028	BRCA	ICGC	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation altering degron motif	0.5944
p.R756Q	DO230336	COCA	ICGC	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.3056
p.R756W	DO227802	COCA	ICGC	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.3056
p.R764Q	DO227444	EOPC	ICGC	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.0833
p.R764W	DO233737	GACA	ICGC	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.0833
p.T745M	DO233855	GACA	ICGC	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation altering degron motif	0.7423
p.E739K	DO23438	LINC	ICGC	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.1667
p.R758W	DO228371	MALY	ICGC	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.25
p.R758W	SIDM00879	Breast Carcinoma	GDSC	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.25
p.R758W	SIDM01008	B-Cell Non-Hodgkin's Lymphoma	GDSC	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.25
p.R758W	ACH-000315	Lymphoma	CCLE	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.25
p.A755T	DO229216	THCA	ICGC	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation altering degron motif	0.7139
p.S738P	DO229211	THCA	ICGC	TDTSSAEVPSA	DEG_COP1_1	745:755	Mutation rewiring degron network	0.1389

Kaplan plot for SFMBT2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SFMBT2

UniProt ID: Q5VUG0

Entrez ID: 57713

Protein name: Scm-like with four MBT domains protein 2 (Scm-like with 4 MBT domains protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SFMBT2 in