DegronMD

Uniprot ID: Q5VUG0

Source protein: Scm-like with four MBT domains protein 2

Source gene: SFMBT2

Class: DEG_COP1_1

Location: 745:755

E3 ligase: COP1

DEGRON score: 0.9631

ASA_SCORE: 82.5545

COIL: 0.8282

CONS_SCORE: 0.4447

DSS_SCORE: 0.775

HELIX: 0.1384

FCONS_SCORE: 1.0655

RIG_SCORE: 0.6194

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R741L	TCGA-51-6867	LUSC	TCGA	TDTSSAEVPSA	DEG_COP1_1	0.2222
p.R741L	DO26477	LUSC	ICGC	TDTSSAEVPSA	DEG_COP1_1	0.2222
p.R758Q	TCGA-AG-3574	READ	TCGA	TDTSSAEVPSA	DEG_COP1_1	0.25
p.R758Q	TCGA-EY-A1GV	UCEC	TCGA	TDTSSAEVPSA	DEG_COP1_1	0.25
p.R758Q	DO222542	MELA	ICGC	TDTSSAEVPSA	DEG_COP1_1	0.25
p.R758Q	DO37267	READ	ICGC	TDTSSAEVPSA	DEG_COP1_1	0.25
p.R758Q	DO42785	UCEC	ICGC	TDTSSAEVPSA	DEG_COP1_1	0.25
p.R758Q	SIDM00933	Breast Carcinoma	GDSC	TDTSSAEVPSA	DEG_COP1_1	0.25
p.V761I	TCGA-BG-A221	UCEC	TCGA	TDTSSAEVPSA	DEG_COP1_1	0.1667
p.V761I	DO42384	UCEC	ICGC	TDTSSAEVPSA	DEG_COP1_1	0.1667
p.R741Q	TCGA-CS-4944	LGG	TCGA	TDTSSAEVPSA	DEG_COP1_1	0.2222
p.R741Q	DO22512	LGG	ICGC	TDTSSAEVPSA	DEG_COP1_1	0.2222
p.R741Q	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	TDTSSAEVPSA	DEG_COP1_1	0.2222
p.R741Q	ACH-000843	Lung Cancer	CCLE	TDTSSAEVPSA	DEG_COP1_1	0.2222
p.R741Q	ACH-001648	Prostate Cancer	CCLE	TDTSSAEVPSA	DEG_COP1_1	0.2222
p.R741Q	HARA	lung	COSMIC	TDTSSAEVPSA	DEG_COP1_1	0.2222
p.A750V	TCGA-D1-A103	UCEC	TCGA	TDTSSAEVPSA	DEG_COP1_1	0.5825
p.A750V	TCGA-TQ-A7RJ	LGG	TCGA	TDTSSAEVPSA	DEG_COP1_1	0.5825
p.A750V	DO219853	LGG	ICGC	TDTSSAEVPSA	DEG_COP1_1	0.5825
p.A750V	DO42312	UCEC	ICGC	TDTSSAEVPSA	DEG_COP1_1	0.5825
p.S748L	TCGA-N5-A4RJ	UCS	TCGA	TDTSSAEVPSA	DEG_COP1_1	0.6556
p.V761A	TCGA-UB-A7MB	LIHC	TCGA	TDTSSAEVPSA	DEG_COP1_1	0.1667
p.V761A	DO52318	LIHC	ICGC	TDTSSAEVPSA	DEG_COP1_1	0.1667
p.T747N	DO225028	BRCA	ICGC	TDTSSAEVPSA	DEG_COP1_1	0.5944
p.R756Q	DO230336	COCA	ICGC	TDTSSAEVPSA	DEG_COP1_1	0.3056
p.R756W	DO227802	COCA	ICGC	TDTSSAEVPSA	DEG_COP1_1	0.3056
p.R764Q	DO227444	EOPC	ICGC	TDTSSAEVPSA	DEG_COP1_1	0.0833
p.R764W	DO233737	GACA	ICGC	TDTSSAEVPSA	DEG_COP1_1	0.0833
p.T745M	DO233855	GACA	ICGC	TDTSSAEVPSA	DEG_COP1_1	0.7423
p.E739K	DO23438	LINC	ICGC	TDTSSAEVPSA	DEG_COP1_1	0.1667
p.R758W	DO228371	MALY	ICGC	TDTSSAEVPSA	DEG_COP1_1	0.25
p.R758W	SIDM00879	Breast Carcinoma	GDSC	TDTSSAEVPSA	DEG_COP1_1	0.25
p.R758W	SIDM01008	B-Cell Non-Hodgkin's Lymphoma	GDSC	TDTSSAEVPSA	DEG_COP1_1	0.25
p.R758W	ACH-000315	Lymphoma	CCLE	TDTSSAEVPSA	DEG_COP1_1	0.25
p.A755T	DO229216	THCA	ICGC	TDTSSAEVPSA	DEG_COP1_1	0.7139
p.S738P	DO229211	THCA	ICGC	TDTSSAEVPSA	DEG_COP1_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TDTSSAEVPSA

Degron related mutations and impact score

Drug responses associated with SFMBT2 mutations

All proteins holding degron of TDTSSAEVPSA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VUG0	Scm-like with four MBT domains protein 2	DEG_COP1_1	745:755	TDTSSAEVPSA	COP1	0.9631	More...