DegronMD - Q5VWM3(PRAMEF18)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L147W	SIDM00461	Acute Myeloid Leukemia	GDSC	LKVFMD	LIG_APCC_ABBA_1	147:152	Mutation altering degron motif	0.7015
p.L147W	SIDM00043	Head and Neck Carcinoma	GDSC	LKVFMD	LIG_APCC_ABBA_1	147:152	Mutation altering degron motif	0.7015
p.E157K	SIDM01175	Other Sarcomas	GDSC	LKVFMD	LIG_APCC_ABBA_1	147:152	Mutation rewiring degron network	0.1944
p.E157K	SIDM00685	Glioblastoma	GDSC	LKVFMD	LIG_APCC_ABBA_1	147:152	Mutation rewiring degron network	0.1944
p.E162K	SIDM00190	Melanoma	GDSC	LKVFMD	LIG_APCC_ABBA_1	147:152	Mutation rewiring degron network	0.0556
p.R140K	SIDM00520	Mesothelioma	GDSC	LKVFMD	LIG_APCC_ABBA_1	147:152	Mutation rewiring degron network	0.1389
p.D152N	SIDM00126	Melanoma	GDSC	LKVFMD	LIG_APCC_ABBA_1	147:152	Mutation altering degron motif	0.6932
p.K156R	SIDM01147	Gastric Carcinoma	GDSC	LKVFMD	LIG_APCC_ABBA_1	147:152	Mutation substituting flanking lysine	0.3333
p.P146L	SIDM00179	Melanoma	GDSC	LKVFMD	LIG_APCC_ABBA_1	147:152	Mutation rewiring degron network	0.3056
p.M160V	SIDM01494	Glioblastoma	GDSC	LKVFMD	LIG_APCC_ABBA_1	147:152	Mutation rewiring degron network	0.1111
p.M160V	SIDM01391	Neuroblastoma	GDSC	LKVFMD	LIG_APCC_ABBA_1	147:152	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons