DegronMD

Uniprot ID: Q5VWM3

Source protein: PRAME family member 18

Source gene: PRAMEF18

Class: LIG_APCC_ABBA_1

Location: 147:152

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5218

ASA_SCORE: 47.4167

COIL: 0.1768

CONS_SCORE: 0.6689

DSS_SCORE: 0.2157

HELIX: 0.094

FCONS_SCORE: 1.3218

RIG_SCORE: 0.9017

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L147W	SIDM00461	Acute Myeloid Leukemia	GDSC	LKVFMD	LIG_APCC_ABBA_1	0.7015
p.L147W	SIDM00043	Head and Neck Carcinoma	GDSC	LKVFMD	LIG_APCC_ABBA_1	0.7015
p.E157K	SIDM01175	Other Sarcomas	GDSC	LKVFMD	LIG_APCC_ABBA_1	0.1944
p.E157K	SIDM00685	Glioblastoma	GDSC	LKVFMD	LIG_APCC_ABBA_1	0.1944
p.E162K	SIDM00190	Melanoma	GDSC	LKVFMD	LIG_APCC_ABBA_1	0.0556
p.R140K	SIDM00520	Mesothelioma	GDSC	LKVFMD	LIG_APCC_ABBA_1	0.1389
p.D152N	SIDM00126	Melanoma	GDSC	LKVFMD	LIG_APCC_ABBA_1	0.6932
p.K156R	SIDM01147	Gastric Carcinoma	GDSC	LKVFMD	LIG_APCC_ABBA_1	0.3333
p.P146L	SIDM00179	Melanoma	GDSC	LKVFMD	LIG_APCC_ABBA_1	0.3056
p.M160V	SIDM01494	Glioblastoma	GDSC	LKVFMD	LIG_APCC_ABBA_1	0.1111
p.M160V	SIDM01391	Neuroblastoma	GDSC	LKVFMD	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VWM3	PRAME family member 18	LIG_APCC_ABBA_1	147:152	LKVFMD	APC,CDC20,FZR1	0.5218	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons