DegronMD - Q5VY09(IER5)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R194G	DO229010	COCA	ICGC	PPGTPAAT	DEG_SCF_FBW7_1	185:192	Mutation rewiring degron network	0.2778
p.R194G	DO229016	COCA	ICGC	PPGTPAAT	DEG_SCF_FBW7_1	185:192	Mutation rewiring degron network	0.2778
p.R194G	DO229005	COCA	ICGC	PPGTPAAT	DEG_SCF_FBW7_1	185:192	Mutation rewiring degron network	0.2778
p.R194G	DO228941	LICA	ICGC	PPGTPAAT	DEG_SCF_FBW7_1	185:192	Mutation rewiring degron network	0.2778
p.R194G	DO218886	SKCA	ICGC	PPGTPAAT	DEG_SCF_FBW7_1	185:192	Mutation rewiring degron network	0.2778
p.Q202R	DO229016	COCA	ICGC	PPGTPAAT	DEG_SCF_FBW7_1	185:192	Mutation rewiring degron network	0.0556
p.Q202R	DO229005	COCA	ICGC	PPGTPAAT	DEG_SCF_FBW7_1	185:192	Mutation rewiring degron network	0.0556
p.C176S	DO234347	ESAD	ICGC	PPGTPAAT	DEG_SCF_FBW7_1	185:192	Mutation rewiring degron network	0.0833
p.D184G	DO233766	GACA	ICGC	PPGTPAAT	DEG_SCF_FBW7_1	185:192	Mutation rewiring degron network	0.3056
p.D184V	DO23298	LINC	ICGC	PPGTPAAT	DEG_SCF_FBW7_1	185:192	Mutation rewiring degron network	0.3056
p.A200T	DO25847	LUAD	ICGC	PPGTPAAT	DEG_SCF_FBW7_1	185:192	Mutation rewiring degron network	0.1111
p.E183G	DO219881	SKCA	ICGC	PPGTPAAT	DEG_SCF_FBW7_1	185:192	Mutation rewiring degron network	0.2778
p.A190T	ACH-000989	Colon/Colorectal Cancer	CCLE	PPGTPAAT	DEG_SCF_FBW7_1	185:192	Mutation altering degron motif	0.6028

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons