DegronMD

Uniprot ID: Q5VY09

Source protein: Immediate early response gene 5 protein

Source gene: IER5

Class: DEG_SCF_FBW7_1

Location: 185:192

E3 ligase: FBXW7

DEGRON score: 0.9898

ASA_SCORE: 71.6625

COIL: 0.9321

CONS_SCORE: 0.2452

DSS_SCORE: 0.2706

HELIX: 0.034

FCONS_SCORE: 0.8171

RIG_SCORE: 0.6011

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R194G	DO229010	COCA	ICGC	PPGTPAAT	DEG_SCF_FBW7_1	0.2778
p.R194G	DO229016	COCA	ICGC	PPGTPAAT	DEG_SCF_FBW7_1	0.2778
p.R194G	DO229005	COCA	ICGC	PPGTPAAT	DEG_SCF_FBW7_1	0.2778
p.R194G	DO228941	LICA	ICGC	PPGTPAAT	DEG_SCF_FBW7_1	0.2778
p.R194G	DO218886	SKCA	ICGC	PPGTPAAT	DEG_SCF_FBW7_1	0.2778
p.Q202R	DO229016	COCA	ICGC	PPGTPAAT	DEG_SCF_FBW7_1	0.0556
p.Q202R	DO229005	COCA	ICGC	PPGTPAAT	DEG_SCF_FBW7_1	0.0556
p.C176S	DO234347	ESAD	ICGC	PPGTPAAT	DEG_SCF_FBW7_1	0.0833
p.D184G	DO233766	GACA	ICGC	PPGTPAAT	DEG_SCF_FBW7_1	0.3056
p.D184V	DO23298	LINC	ICGC	PPGTPAAT	DEG_SCF_FBW7_1	0.3056
p.A200T	DO25847	LUAD	ICGC	PPGTPAAT	DEG_SCF_FBW7_1	0.1111
p.E183G	DO219881	SKCA	ICGC	PPGTPAAT	DEG_SCF_FBW7_1	0.2778
p.A190T	ACH-000989	Colon/Colorectal Cancer	CCLE	PPGTPAAT	DEG_SCF_FBW7_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VY09	Immediate early response gene 5 protein	DEG_SCF_FBW7_1	185:192	PPGTPAAT	FBXW7	0.9898	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons