DegronMD - Q5VZI3(TMEM268)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L230F	SIDM00001	Other Blood Cancers	GDSC	LRSRLSQLC	DEG_APCC_DBOX_1	225:233	Mutation altering degron motif	0.6981
p.E238V	SIDM00234	Other Solid Cancers	GDSC	LRSRLSQLC	DEG_APCC_DBOX_1	225:233	Mutation rewiring degron network	0.1944
p.E238V	SIDM00024	Non-Cancerous	GDSC	LRSRLSQLC	DEG_APCC_DBOX_1	225:233	Mutation rewiring degron network	0.1944
p.S242N	SIDM01063	Acute Myeloid Leukemia	GDSC	LRSRLSQLC	DEG_APCC_DBOX_1	225:233	Mutation rewiring degron network	0.0833
p.S242N	HD-MY-Z	haematopoietic and lymphoid tissue	COSMIC	LRSRLSQLC	DEG_APCC_DBOX_1	225:233	Mutation rewiring degron network	0.0833
p.V236A	SIDM00612	Glioma	GDSC	LRSRLSQLC	DEG_APCC_DBOX_1	225:233	Mutation rewiring degron network	0.25
p.V236A	SIDM01622	Breast Carcinoma	GDSC	LRSRLSQLC	DEG_APCC_DBOX_1	225:233	Mutation rewiring degron network	0.25
p.S241N	HD-MY-Z	haematopoietic and lymphoid tissue	COSMIC	LRSRLSQLC	DEG_APCC_DBOX_1	225:233	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons