DegronMD

Uniprot ID: Q5VZI3

Source protein: Transmembrane protein 268

Source gene: TMEM268

Class: DEG_APCC_DBOX_1

Location: 225:233

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9058

ASA_SCORE: 74.9444

COIL: 0.4391

CONS_SCORE: 0.7149

DSS_SCORE: 0.2534

HELIX: 0.4579

FCONS_SCORE: 1.3826

RIG_SCORE: 0.7949

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L230F	SIDM00001	Other Blood Cancers	GDSC	LRSRLSQLC	DEG_APCC_DBOX_1	0.6981
p.E238V	SIDM00234	Other Solid Cancers	GDSC	LRSRLSQLC	DEG_APCC_DBOX_1	0.1944
p.E238V	SIDM00024	Non-Cancerous	GDSC	LRSRLSQLC	DEG_APCC_DBOX_1	0.1944
p.S242N	SIDM01063	Acute Myeloid Leukemia	GDSC	LRSRLSQLC	DEG_APCC_DBOX_1	0.0833
p.S242N	HD-MY-Z	haematopoietic_and_lymphoid_tissue	COSMIC	LRSRLSQLC	DEG_APCC_DBOX_1	0.0833
p.V236A	SIDM00612	Glioma	GDSC	LRSRLSQLC	DEG_APCC_DBOX_1	0.25
p.V236A	SIDM01622	Breast Carcinoma	GDSC	LRSRLSQLC	DEG_APCC_DBOX_1	0.25
p.S241N	HD-MY-Z	haematopoietic_and_lymphoid_tissue	COSMIC	LRSRLSQLC	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VZI3	Transmembrane protein 268	DEG_APCC_DBOX_1	225:233	LRSRLSQLC	APC,CDC20,FZR1	0.9058	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons