DegronMD - Q5XG92(CES4A)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P55L	TCGA-85-7844	LUSC	TCGA	SRPPLGILR	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.2778
p.I48M	TCGA-B5-A11R	UCEC	TCGA	SRPPLGILR	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.0833
p.F56L	TCGA-BS-A0UF	UCEC	TCGA	SRPPLGILR	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.3056
p.F56L	DO41488	UCEC	ICGC	SRPPLGILR	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.3056
p.F56L	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	SRPPLGILR	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.3056
p.F56L	ACH-000777	Esophageal Cancer	CCLE	SRPPLGILR	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.3056
p.G62C	TCGA-D3-A2JP	SKCM	TCGA	SRPPLGILR	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.6489
p.P68H	TCGA-DU-6392	LGG	TCGA	SRPPLGILR	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.25
p.P71L	TCGA-EE-A2MS	SKCM	TCGA	SRPPLGILR	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.1667
p.P71L	DO37567	SKCM	ICGC	SRPPLGILR	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.1667
p.P47L	TCGA-EE-A3AC	SKCM	TCGA	SRPPLGILR	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.0556
p.P47L	DO37631	SKCM	ICGC	SRPPLGILR	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.0556
p.I71M	DO43787	UCEC	ICGC	SRPPLGILR	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.1667
p.P71S	SIDM01092	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRPPLGILR	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.1667
p.P71S	ACH-002301	Lymphoma	CCLE	SRPPLGILR	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.1667
p.P71S	RF-48	stomach	COSMIC	SRPPLGILR	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.1667
p.V54L	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	SRPPLGILR	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.25
p.V54L	ACH-000873	Esophageal Cancer	CCLE	SRPPLGILR	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.25
p.V54L	KYSE-270	oesophagus	COSMIC	SRPPLGILR	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.25

Kaplan plot for CES4A in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CES4A

UniProt ID: Q5XG92

Entrez ID: 283848

Protein name: Carboxylesterase 4A (EC 3.1.1.-)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CES4A in