DegronMD

Uniprot ID: Q5XG92

Source protein: Carboxylesterase 4A

Source gene: CES4A

Class: DEG_APCC_DBOX_1

Location: 57:65

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9927

ASA_SCORE: 71.2

COIL: 0.8779

CONS_SCORE: 0.6786

DSS_SCORE: 0.3658

HELIX: 0.0676

FCONS_SCORE: 1.4136

RIG_SCORE: 0.759

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P55L	TCGA-85-7844	LUSC	TCGA	SRPPLGILR	DEG_APCC_DBOX_1	0.2778
p.I48M	TCGA-B5-A11R	UCEC	TCGA	SRPPLGILR	DEG_APCC_DBOX_1	0.0833
p.F56L	TCGA-BS-A0UF	UCEC	TCGA	SRPPLGILR	DEG_APCC_DBOX_1	0.3056
p.F56L	DO41488	UCEC	ICGC	SRPPLGILR	DEG_APCC_DBOX_1	0.3056
p.F56L	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	SRPPLGILR	DEG_APCC_DBOX_1	0.3056
p.F56L	ACH-000777	Esophageal Cancer	CCLE	SRPPLGILR	DEG_APCC_DBOX_1	0.3056
p.G62C	TCGA-D3-A2JP	SKCM	TCGA	SRPPLGILR	DEG_APCC_DBOX_1	0.6489
p.P68H	TCGA-DU-6392	LGG	TCGA	SRPPLGILR	DEG_APCC_DBOX_1	0.25
p.P71L	TCGA-EE-A2MS	SKCM	TCGA	SRPPLGILR	DEG_APCC_DBOX_1	0.1667
p.P71L	DO37567	SKCM	ICGC	SRPPLGILR	DEG_APCC_DBOX_1	0.1667
p.P47L	TCGA-EE-A3AC	SKCM	TCGA	SRPPLGILR	DEG_APCC_DBOX_1	0.0556
p.P47L	DO37631	SKCM	ICGC	SRPPLGILR	DEG_APCC_DBOX_1	0.0556
p.I71M	DO43787	UCEC	ICGC	SRPPLGILR	DEG_APCC_DBOX_1	0.1667
p.P71S	SIDM01092	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRPPLGILR	DEG_APCC_DBOX_1	0.1667
p.P71S	ACH-002301	Lymphoma	CCLE	SRPPLGILR	DEG_APCC_DBOX_1	0.1667
p.P71S	RF-48	stomach	COSMIC	SRPPLGILR	DEG_APCC_DBOX_1	0.1667
p.V54L	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	SRPPLGILR	DEG_APCC_DBOX_1	0.25
p.V54L	ACH-000873	Esophageal Cancer	CCLE	SRPPLGILR	DEG_APCC_DBOX_1	0.25
p.V54L	KYSE-270	oesophagus	COSMIC	SRPPLGILR	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5XG92	Carboxylesterase 4A	DEG_APCC_DBOX_1	57:65	SRPPLGILR	APC,CDC20,FZR1	0.9927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons