DegronMD - Q5XX13(FBXW10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M953L	TCGA-27-1835	GBM	TCGA	LAPQVGTATLSL	DEG_ODPH_VHL_1	954:965	Mutation rewiring degron network	0.3056
p.M953L	DO228654	LICA	ICGC	LAPQVGTATLSL	DEG_ODPH_VHL_1	954:965	Mutation rewiring degron network	0.3056
p.A975T	TCGA-A5-A0G2	UCEC	TCGA	LAPQVGTATLSL	DEG_ODPH_VHL_1	954:965	Mutation rewiring degron network	0.0556
p.R952C	TCGA-AA-3845	COAD	TCGA	LAPQVGTATLSL	DEG_ODPH_VHL_1	954:965	Mutation rewiring degron network	0.2778
p.R952C	DO10020	COAD	ICGC	LAPQVGTATLSL	DEG_ODPH_VHL_1	954:965	Mutation rewiring degron network	0.2778
p.Q946H	TCGA-AX-A06F	UCEC	TCGA	LAPQVGTATLSL	DEG_ODPH_VHL_1	954:965	Mutation rewiring degron network	0.1111
p.R971C	TCGA-AZ-4315	COAD	TCGA	LAPQVGTATLSL	DEG_ODPH_VHL_1	954:965	Mutation rewiring degron network	0.1667
p.R971C	DO8842	COAD	ICGC	LAPQVGTATLSL	DEG_ODPH_VHL_1	954:965	Mutation rewiring degron network	0.1667
p.R971C	DO229054	LICA	ICGC	LAPQVGTATLSL	DEG_ODPH_VHL_1	954:965	Mutation rewiring degron network	0.1667
p.K973N	DO48424	BLCA	ICGC	LAPQVGTATLSL	DEG_ODPH_VHL_1	954:965	Mutation rewiring degron network	0.1111
p.V965A	DO223036	ESCA	ICGC	LAPQVGTATLSL	DEG_ODPH_VHL_1	954:965	Mutation altering degron motif	0.6936
p.V965A	DO233079	GACA	ICGC	LAPQVGTATLSL	DEG_ODPH_VHL_1	954:965	Mutation altering degron motif	0.6936
p.V965A	DO229508	LAML	ICGC	LAPQVGTATLSL	DEG_ODPH_VHL_1	954:965	Mutation altering degron motif	0.6936
p.V965A	DO225399	LAML	ICGC	LAPQVGTATLSL	DEG_ODPH_VHL_1	954:965	Mutation altering degron motif	0.6936
p.V965A	DO231102	LUSC	ICGC	LAPQVGTATLSL	DEG_ODPH_VHL_1	954:965	Mutation altering degron motif	0.6936
p.Y973C	SIDM00938	Breast Carcinoma	GDSC	LAPQVGTATLSL	DEG_ODPH_VHL_1	954:965	Mutation rewiring degron network	0.1111
p.Y973C	ACH-000902	Breast Cancer	CCLE	LAPQVGTATLSL	DEG_ODPH_VHL_1	954:965	Mutation rewiring degron network	0.1111
p.Y973C	CAL-148	breast	COSMIC	LAPQVGTATLSL	DEG_ODPH_VHL_1	954:965	Mutation rewiring degron network	0.1111
p.R971H	SIDM01588	Endometrial Carcinoma	GDSC	LAPQVGTATLSL	DEG_ODPH_VHL_1	954:965	Mutation rewiring degron network	0.1667
p.A953P	MM1S	haematopoietic and lymphoid tissue	COSMIC	LAPQVGTATLSL	DEG_ODPH_VHL_1	954:965	Mutation rewiring degron network	0.3056
p.V960A	KYSE-520	oesophagus	COSMIC	LAPQVGTATLSL	DEG_ODPH_VHL_1	954:965	Mutation altering degron motif	0.6936

Kaplan plot for FBXW10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FBXW10

UniProt ID: Q5XX13

Entrez ID: 10517

Protein name: F-box/WD repeat-containing protein 10 (F-box and WD-40 domain-containing protein 10) (Ubiquitin ligase-specificity factor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FBXW10 in