DegronMD

Uniprot ID: Q5XX13

Source protein: F-box/WD repeat-containing protein 10

Source gene: FBXW10

Class: DEG_ODPH_VHL_1

Location: 954:965

E3 ligase: VHL

DEGRON score: 0.9958

ASA_SCORE: 80.0833

COIL: 0.8212

CONS_SCORE: 0.2654

DSS_SCORE: 0.3564

HELIX: 0.1267

FCONS_SCORE: 0.9128

RIG_SCORE: 0.7766

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M953L	TCGA-27-1835	GBM	TCGA	LAPQVGTATLSL	DEG_ODPH_VHL_1	0.3056
p.M953L	DO228654	LICA	ICGC	LAPQVGTATLSL	DEG_ODPH_VHL_1	0.3056
p.A975T	TCGA-A5-A0G2	UCEC	TCGA	LAPQVGTATLSL	DEG_ODPH_VHL_1	0.0556
p.R952C	TCGA-AA-3845	COAD	TCGA	LAPQVGTATLSL	DEG_ODPH_VHL_1	0.2778
p.R952C	DO10020	COAD	ICGC	LAPQVGTATLSL	DEG_ODPH_VHL_1	0.2778
p.Q946H	TCGA-AX-A06F	UCEC	TCGA	LAPQVGTATLSL	DEG_ODPH_VHL_1	0.1111
p.R971C	TCGA-AZ-4315	COAD	TCGA	LAPQVGTATLSL	DEG_ODPH_VHL_1	0.1667
p.R971C	DO8842	COAD	ICGC	LAPQVGTATLSL	DEG_ODPH_VHL_1	0.1667
p.R971C	DO229054	LICA	ICGC	LAPQVGTATLSL	DEG_ODPH_VHL_1	0.1667
p.K973N	DO48424	BLCA	ICGC	LAPQVGTATLSL	DEG_ODPH_VHL_1	0.1111
p.V965A	DO223036	ESCA	ICGC	LAPQVGTATLSL	DEG_ODPH_VHL_1	0.6936
p.V965A	DO233079	GACA	ICGC	LAPQVGTATLSL	DEG_ODPH_VHL_1	0.6936
p.V965A	DO229508	LAML	ICGC	LAPQVGTATLSL	DEG_ODPH_VHL_1	0.6936
p.V965A	DO225399	LAML	ICGC	LAPQVGTATLSL	DEG_ODPH_VHL_1	0.6936
p.V965A	DO231102	LUSC	ICGC	LAPQVGTATLSL	DEG_ODPH_VHL_1	0.6936
p.Y973C	SIDM00938	Breast Carcinoma	GDSC	LAPQVGTATLSL	DEG_ODPH_VHL_1	0.1111
p.Y973C	ACH-000902	Breast Cancer	CCLE	LAPQVGTATLSL	DEG_ODPH_VHL_1	0.1111
p.Y973C	CAL-148	breast	COSMIC	LAPQVGTATLSL	DEG_ODPH_VHL_1	0.1111
p.R971H	SIDM01588	Endometrial Carcinoma	GDSC	LAPQVGTATLSL	DEG_ODPH_VHL_1	0.1667
p.A953P	MM1S	haematopoietic_and_lymphoid_tissue	COSMIC	LAPQVGTATLSL	DEG_ODPH_VHL_1	0.3056
p.V960A	KYSE-520	oesophagus	COSMIC	LAPQVGTATLSL	DEG_ODPH_VHL_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5XX13	F-box/WD repeat-containing protein 10	DEG_ODPH_VHL_1	954:965	LAPQVGTATLSL	VHL	0.9958	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons