DegronMD - Q64LD2(WDR25)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G244C	TCGA-06-5416	GBM	TCGA	PRKVLFHLR	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.3056
p.G244C	DO10880	GBM	ICGC	PRKVLFHLR	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.3056
p.R236Q	TCGA-A5-A0G2	UCEC	TCGA	PRKVLFHLR	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.7329
p.R236Q	DO41235	UCEC	ICGC	PRKVLFHLR	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.7329
p.Y229H	TCGA-AR-A2LL	BRCA	TCGA	PRKVLFHLR	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1667
p.Y229H	DO1702	BRCA	ICGC	PRKVLFHLR	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1667
p.L242P	TCGA-AX-A2IN	UCEC	TCGA	PRKVLFHLR	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.7582
p.L242P	DO42328	UCEC	ICGC	PRKVLFHLR	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.7582
p.F240L	TCGA-CV-7427	HNSC	TCGA	PRKVLFHLR	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.587
p.F240L	DO14286	HNSC	ICGC	PRKVLFHLR	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.587
p.H241Y	TCGA-D3-A8GL	SKCM	TCGA	PRKVLFHLR	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.6118
p.H241Y	DO50287	SKCM	ICGC	PRKVLFHLR	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.6118
p.P248T	TCGA-DZ-6133	KIRP	TCGA	PRKVLFHLR	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1944
p.P248T	DO20762	KIRP	ICGC	PRKVLFHLR	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1944
p.T251I	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	PRKVLFHLR	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1111
p.T251I	ACH-000605	Esophageal Cancer	CCLE	PRKVLFHLR	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1111
p.T251I	TE-6	oesophagus	COSMIC	PRKVLFHLR	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1111
p.P248S	SIDM00839	Colorectal Carcinoma	GDSC	PRKVLFHLR	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1944
p.P248S	ACH-000950	Colon/Colorectal Cancer	CCLE	PRKVLFHLR	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1944
p.P248S	LoVo	large intestine	COSMIC	PRKVLFHLR	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1944
p.D237N	Mewo	skin	COSMIC	PRKVLFHLR	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.6932
p.S225F	KYSE-180	oesophagus	COSMIC	PRKVLFHLR	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.0556
p.R239W	CPC-N	lung	COSMIC	PRKVLFHLR	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.8634

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WDR25

UniProt ID: Q64LD2

Entrez ID: 79446

Protein name: WD repeat-containing protein 25

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WDR25 in