DegronMD

Uniprot ID: Q64LD2

Source protein: WD repeat-containing protein 25

Source gene: WDR25

Class: DEG_APCC_DBOX_1

Location: 235:243

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6414

ASA_SCORE: 70.8111

COIL: 0.3538

CONS_SCORE: 0.5406

DSS_SCORE: 0.2988

HELIX: 0.0103

FCONS_SCORE: 0.9516

RIG_SCORE: 0.845

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G244C	TCGA-06-5416	GBM	TCGA	PRKVLFHLR	DEG_APCC_DBOX_1	0.3056
p.G244C	DO10880	GBM	ICGC	PRKVLFHLR	DEG_APCC_DBOX_1	0.3056
p.R236Q	TCGA-A5-A0G2	UCEC	TCGA	PRKVLFHLR	DEG_APCC_DBOX_1	0.7329
p.R236Q	DO41235	UCEC	ICGC	PRKVLFHLR	DEG_APCC_DBOX_1	0.7329
p.Y229H	TCGA-AR-A2LL	BRCA	TCGA	PRKVLFHLR	DEG_APCC_DBOX_1	0.1667
p.Y229H	DO1702	BRCA	ICGC	PRKVLFHLR	DEG_APCC_DBOX_1	0.1667
p.L242P	TCGA-AX-A2IN	UCEC	TCGA	PRKVLFHLR	DEG_APCC_DBOX_1	0.7582
p.L242P	DO42328	UCEC	ICGC	PRKVLFHLR	DEG_APCC_DBOX_1	0.7582
p.F240L	TCGA-CV-7427	HNSC	TCGA	PRKVLFHLR	DEG_APCC_DBOX_1	0.587
p.F240L	DO14286	HNSC	ICGC	PRKVLFHLR	DEG_APCC_DBOX_1	0.587
p.H241Y	TCGA-D3-A8GL	SKCM	TCGA	PRKVLFHLR	DEG_APCC_DBOX_1	0.6118
p.H241Y	DO50287	SKCM	ICGC	PRKVLFHLR	DEG_APCC_DBOX_1	0.6118
p.P248T	TCGA-DZ-6133	KIRP	TCGA	PRKVLFHLR	DEG_APCC_DBOX_1	0.1944
p.P248T	DO20762	KIRP	ICGC	PRKVLFHLR	DEG_APCC_DBOX_1	0.1944
p.T251I	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	PRKVLFHLR	DEG_APCC_DBOX_1	0.1111
p.T251I	ACH-000605	Esophageal Cancer	CCLE	PRKVLFHLR	DEG_APCC_DBOX_1	0.1111
p.T251I	TE-6	oesophagus	COSMIC	PRKVLFHLR	DEG_APCC_DBOX_1	0.1111
p.P248S	SIDM00839	Colorectal Carcinoma	GDSC	PRKVLFHLR	DEG_APCC_DBOX_1	0.1944
p.P248S	ACH-000950	Colon/Colorectal Cancer	CCLE	PRKVLFHLR	DEG_APCC_DBOX_1	0.1944
p.P248S	LoVo	large_intestine	COSMIC	PRKVLFHLR	DEG_APCC_DBOX_1	0.1944
p.D237N	Mewo	skin	COSMIC	PRKVLFHLR	DEG_APCC_DBOX_1	0.6932
p.S225F	KYSE-180	oesophagus	COSMIC	PRKVLFHLR	DEG_APCC_DBOX_1	0.0556
p.R239W	CPC-N	lung	COSMIC	PRKVLFHLR	DEG_APCC_DBOX_1	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q64LD2	WD repeat-containing protein 25	DEG_APCC_DBOX_1	235:243	PRKVLFHLR	APC,CDC20,FZR1	0.6414	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons