DegronMD - Q66K66(TMEM198)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S251R	TCGA-14-1794	GBM	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.2222
p.S251R	DO13024	GBM	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.2222
p.R263W	TCGA-55-8506	LUAD	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.7523
p.R263W	DO227996	COCA	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.7523
p.R263W	DO45390	LUAD	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.7523
p.R255Q	TCGA-5M-AATE	COAD	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.6218
p.R255Q	DO223704	COAD	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.6218
p.R255Q	SIDM00333	Endometrial Carcinoma	GDSC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.6218
p.R255Q	ACH-000988	Endometrial/Uterine Cancer	CCLE	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.6218
p.R255Q	MFE-319	endometrium	COSMIC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.6218
p.R268C	TCGA-A5-A0G1	UCEC	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.1944
p.R268C	TCGA-AA-A010	COAD	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.1944
p.R268C	DO42472	UCEC	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.1944
p.R261W	TCGA-AP-A051	UCEC	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.7523
p.R261W	DO42673	UCEC	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.7523
p.R254H	TCGA-AP-A1DK	UCEC	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.3056
p.R254H	DO42033	UCEC	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.3056
p.R256H	TCGA-CV-7425	HNSC	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.8244
p.R256H	TCGA-HU-A4GN	STAD	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.8244
p.R256H	DO15687	HNSC	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.8244
p.R256H	DO47833	STAD	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.8244
p.D267V	TCGA-CZ-4863	KIRC	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.2222
p.D267V	DO18691	KIRC	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.2222
p.D267E	TCGA-CZ-4863	KIRC	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.2222
p.D267E	DO18691	KIRC	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.2222
p.R268H	TCGA-DI-A1BU	UCEC	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.1944
p.R268H	TCGA-EO-A22R	UCEC	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.1944
p.R268H	TCGA-VQ-A8PP	STAD	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.1944
p.R268H	DO51774	STAD	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.1944
p.R268H	DO42023	UCEC	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.1944
p.R268H	DO42713	UCEC	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.1944
p.R268H	SIDM02077	Colorectal Carcinoma	GDSC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.1944
p.R256C	TCGA-DY-A1DG	READ	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.8301
p.R256C	DO36853	READ	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.8301
p.E270K	TCGA-FW-A3R5	SKCM	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.1389
p.E270K	DO37406	SKCM	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.1389
p.R252W	TCGA-W6-AA0S	CHOL	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.25
p.R261Q	DO222798	COCA	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.6218
p.D267Y	DO228974	LICA	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.2222
p.V257L	DO229022	LICA	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.5654
p.V257L	ACH-002027	Endometrial/Uterine Cancer	CCLE	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.5654
p.R255L	DO229025	LICA	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.7316
p.R254C	DO45299	LIRI	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.3056
p.R273W	DO33776	PACA	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.0556
p.V248A	SIDM00282	Colorectal Carcinoma	GDSC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.1389
p.V248A	CW-2	large intestine	COSMIC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.1389
p.V257A	SIDM01045	Endometrial Carcinoma	GDSC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.5825
p.V257A	ACH-000978	Endometrial/Uterine Cancer	CCLE	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.5825
p.V257A	EN	endometrium	COSMIC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.5825
p.K269N	SIDM00140	Melanoma	GDSC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation substituting flanking lysine	0.2778
p.K269N	ACH-000968	Skin Cancer	CCLE	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation substituting flanking lysine	0.2778
p.K269N	COLO-792	skin	COSMIC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation substituting flanking lysine	0.2778
p.R263Q	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.6218
p.R273Q	SIDM01588	Endometrial Carcinoma	GDSC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.0556
p.R273Q	ACH-000993	Endometrial/Uterine Cancer	CCLE	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.0556
p.V257M	SIDM01619	Endometrial Carcinoma	GDSC	RRVQLMRIR	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.6097

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM198

UniProt ID: Q66K66

Entrez ID: 130612

Protein name: Transmembrane protein 198

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM198 in