DegronMD

Uniprot ID: Q66K66

Source protein: Transmembrane protein 198

Source gene: TMEM198

Class: DEG_APCC_DBOX_1

Location: 255:263

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9654

ASA_SCORE: 123.7

COIL: 0.3208

CONS_SCORE: 0.8246

DSS_SCORE: 0.5269

HELIX: 0.6248

FCONS_SCORE: 1.2057

RIG_SCORE: 0.7887

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S251R	TCGA-14-1794	GBM	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	0.2222
p.S251R	DO13024	GBM	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.2222
p.R263W	TCGA-55-8506	LUAD	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	0.7523
p.R263W	DO227996	COCA	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.7523
p.R263W	DO45390	LUAD	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.7523
p.R255Q	TCGA-5M-AATE	COAD	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	0.6218
p.R255Q	DO223704	COAD	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.6218
p.R255Q	SIDM00333	Endometrial Carcinoma	GDSC	RRVQLMRIR	DEG_APCC_DBOX_1	0.6218
p.R255Q	ACH-000988	Endometrial/Uterine Cancer	CCLE	RRVQLMRIR	DEG_APCC_DBOX_1	0.6218
p.R255Q	MFE-319	endometrium	COSMIC	RRVQLMRIR	DEG_APCC_DBOX_1	0.6218
p.R268C	TCGA-A5-A0G1	UCEC	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	0.1944
p.R268C	TCGA-AA-A010	COAD	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	0.1944
p.R268C	DO42472	UCEC	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.1944
p.R261W	TCGA-AP-A051	UCEC	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	0.7523
p.R261W	DO42673	UCEC	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.7523
p.R254H	TCGA-AP-A1DK	UCEC	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	0.3056
p.R254H	DO42033	UCEC	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.3056
p.R256H	TCGA-CV-7425	HNSC	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	0.8244
p.R256H	TCGA-HU-A4GN	STAD	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	0.8244
p.R256H	DO15687	HNSC	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.8244
p.R256H	DO47833	STAD	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.8244
p.D267V	TCGA-CZ-4863	KIRC	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	0.2222
p.D267V	DO18691	KIRC	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.2222
p.D267E	TCGA-CZ-4863	KIRC	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	0.2222
p.D267E	DO18691	KIRC	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.2222
p.R268H	TCGA-DI-A1BU	UCEC	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	0.1944
p.R268H	TCGA-EO-A22R	UCEC	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	0.1944
p.R268H	TCGA-VQ-A8PP	STAD	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	0.1944
p.R268H	DO51774	STAD	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.1944
p.R268H	DO42023	UCEC	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.1944
p.R268H	DO42713	UCEC	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.1944
p.R268H	SIDM02077	Colorectal Carcinoma	GDSC	RRVQLMRIR	DEG_APCC_DBOX_1	0.1944
p.R256C	TCGA-DY-A1DG	READ	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	0.8301
p.R256C	DO36853	READ	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.8301
p.E270K	TCGA-FW-A3R5	SKCM	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	0.1389
p.E270K	DO37406	SKCM	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.1389
p.R252W	TCGA-W6-AA0S	CHOL	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	0.25
p.R261Q	DO222798	COCA	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.6218
p.D267Y	DO228974	LICA	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.2222
p.V257L	DO229022	LICA	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.5654
p.V257L	ACH-002027	Endometrial/Uterine Cancer	CCLE	RRVQLMRIR	DEG_APCC_DBOX_1	0.5654
p.R255L	DO229025	LICA	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.7316
p.R254C	DO45299	LIRI	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.3056
p.R273W	DO33776	PACA	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.0556
p.V248A	SIDM00282	Colorectal Carcinoma	GDSC	RRVQLMRIR	DEG_APCC_DBOX_1	0.1389
p.V248A	CW-2	large_intestine	COSMIC	RRVQLMRIR	DEG_APCC_DBOX_1	0.1389
p.V257A	SIDM01045	Endometrial Carcinoma	GDSC	RRVQLMRIR	DEG_APCC_DBOX_1	0.5825
p.V257A	ACH-000978	Endometrial/Uterine Cancer	CCLE	RRVQLMRIR	DEG_APCC_DBOX_1	0.5825
p.V257A	EN	endometrium	COSMIC	RRVQLMRIR	DEG_APCC_DBOX_1	0.5825
p.K269N	SIDM00140	Melanoma	GDSC	RRVQLMRIR	DEG_APCC_DBOX_1	0.2778
p.K269N	ACH-000968	Skin Cancer	CCLE	RRVQLMRIR	DEG_APCC_DBOX_1	0.2778
p.K269N	COLO-792	skin	COSMIC	RRVQLMRIR	DEG_APCC_DBOX_1	0.2778
p.R263Q	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	RRVQLMRIR	DEG_APCC_DBOX_1	0.6218
p.R273Q	SIDM01588	Endometrial Carcinoma	GDSC	RRVQLMRIR	DEG_APCC_DBOX_1	0.0556
p.R273Q	ACH-000993	Endometrial/Uterine Cancer	CCLE	RRVQLMRIR	DEG_APCC_DBOX_1	0.0556
p.V257M	SIDM01619	Endometrial Carcinoma	GDSC	RRVQLMRIR	DEG_APCC_DBOX_1	0.6097

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRVQLMRIR

Degron related mutations and impact score

Drug responses associated with TMEM198 mutations

All proteins holding degron of RRVQLMRIR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q66K66	Transmembrane protein 198	DEG_APCC_DBOX_1	255:263	RRVQLMRIR	APC,CDC20,FZR1	0.9654	More...