DegronMD

Uniprot ID: Q66K66

Source protein: Transmembrane protein 198

Source gene: TMEM198

Class: DEG_APCC_DBOX_1

Location: 255:263

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9654

ASA_SCORE: 123.7

COIL: 0.3208

CONS_SCORE: 0.8246

DSS_SCORE: 0.5269

HELIX: 0.6248

FCONS_SCORE: 1.2057

RIG_SCORE: 0.7887

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R256C	TCGA-DY-A1DG	READ	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	0.8301
p.R256C	DO36853	READ	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.8301
p.R256H	TCGA-CV-7425	HNSC	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	0.8244
p.R256H	TCGA-HU-A4GN	STAD	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	0.8244
p.R256H	DO15687	HNSC	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.8244
p.R256H	DO47833	STAD	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.8244
p.R263W	TCGA-55-8506	LUAD	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	0.7523
p.R263W	DO227996	COCA	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.7523
p.R263W	DO45390	LUAD	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.7523
p.R261W	TCGA-AP-A051	UCEC	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	0.7523
p.R261W	DO42673	UCEC	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.7523
p.R255L	DO229025	LICA	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.7316
p.R255Q	TCGA-5M-AATE	COAD	TCGA	RRVQLMRIR	DEG_APCC_DBOX_1	0.6218
p.R255Q	DO223704	COAD	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.6218
p.R255Q	SIDM00333	Endometrial Carcinoma	GDSC	RRVQLMRIR	DEG_APCC_DBOX_1	0.6218
p.R255Q	ACH-000988	Endometrial/Uterine Cancer	CCLE	RRVQLMRIR	DEG_APCC_DBOX_1	0.6218
p.R255Q	MFE-319	endometrium	COSMIC	RRVQLMRIR	DEG_APCC_DBOX_1	0.6218
p.R261Q	DO222798	COCA	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.6218
p.R263Q	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	RRVQLMRIR	DEG_APCC_DBOX_1	0.6218
p.V257M	SIDM01619	Endometrial Carcinoma	GDSC	RRVQLMRIR	DEG_APCC_DBOX_1	0.6097
p.V257A	SIDM01045	Endometrial Carcinoma	GDSC	RRVQLMRIR	DEG_APCC_DBOX_1	0.5825
p.V257A	ACH-000978	Endometrial/Uterine Cancer	CCLE	RRVQLMRIR	DEG_APCC_DBOX_1	0.5825
p.V257A	EN	endometrium	COSMIC	RRVQLMRIR	DEG_APCC_DBOX_1	0.5825
p.V257L	DO229022	LICA	ICGC	RRVQLMRIR	DEG_APCC_DBOX_1	0.5654
p.V257L	ACH-002027	Endometrial/Uterine Cancer	CCLE	RRVQLMRIR	DEG_APCC_DBOX_1	0.5654

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Drug responses associated with TMEM198 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of RRVQLMRIR

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q66K66	Transmembrane protein 198	DEG_APCC_DBOX_1	255:263	RRVQLMRIR	APC,CDC20,FZR1	0.9654	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRVQLMRIR

Degron related mutations and impact score

Drug responses associated with TMEM198 mutations

All proteins holding degron of RRVQLMRIR