DegronMD - Q674X7(KAZN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D737N	TCGA-06-6698	GBM	TCGA	GRLPLGKIG	DEG_APCC_DBOX_1	720:728	Mutation rewiring degron network	0.0833
p.D737N	TCGA-CA-6717	COAD	TCGA	GRLPLGKIG	DEG_APCC_DBOX_1	720:728	Mutation rewiring degron network	0.0833
p.D737N	DO8264	COAD	ICGC	GRLPLGKIG	DEG_APCC_DBOX_1	720:728	Mutation rewiring degron network	0.0833
p.D737N	DO13737	GBM	ICGC	GRLPLGKIG	DEG_APCC_DBOX_1	720:728	Mutation rewiring degron network	0.0833
p.D735Y	TCGA-AA-A00N	COAD	TCGA	GRLPLGKIG	DEG_APCC_DBOX_1	720:728	Mutation rewiring degron network	0.1389
p.D735Y	DO9876	COAD	ICGC	GRLPLGKIG	DEG_APCC_DBOX_1	720:728	Mutation rewiring degron network	0.1389
p.D735Y	ACH-001147	Lymphoma	CCLE	GRLPLGKIG	DEG_APCC_DBOX_1	720:728	Mutation rewiring degron network	0.1389
p.P723S	TCGA-DF-A2KU	UCEC	TCGA	GRLPLGKIG	DEG_APCC_DBOX_1	720:728	Mutation altering degron motif	0.5641
p.P723S	DO223286	UCEC	ICGC	GRLPLGKIG	DEG_APCC_DBOX_1	720:728	Mutation altering degron motif	0.5641
p.E710K	TCGA-ER-A194	SKCM	TCGA	GRLPLGKIG	DEG_APCC_DBOX_1	720:728	Mutation rewiring degron network	0.0556
p.E710K	DO47646	SKCM	ICGC	GRLPLGKIG	DEG_APCC_DBOX_1	720:728	Mutation rewiring degron network	0.0556
p.G730C	DO228974	LICA	ICGC	GRLPLGKIG	DEG_APCC_DBOX_1	720:728	Mutation rewiring degron network	0.2778
p.G728V	DO229031	LICA	ICGC	GRLPLGKIG	DEG_APCC_DBOX_1	720:728	Mutation altering degron motif	0.6421
p.A719S	DO229034	LICA	ICGC	GRLPLGKIG	DEG_APCC_DBOX_1	720:728	Mutation rewiring degron network	0.3056
p.K716E	DO232861	NACA	ICGC	GRLPLGKIG	DEG_APCC_DBOX_1	720:728	Mutation substituting flanking lysine	0.3333
p.D735E	SIDM00845	Burkitt's Lymphoma	GDSC	GRLPLGKIG	DEG_APCC_DBOX_1	720:728	Mutation rewiring degron network	0.1389
p.Y717H	ACH-000990	Endometrial/Uterine Cancer	CCLE	GRLPLGKIG	DEG_APCC_DBOX_1	720:728	Mutation blocking phosphorylation signal	0.6944
p.G725S	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	GRLPLGKIG	DEG_APCC_DBOX_1	720:728	Mutation altering degron motif	0.5882

Kaplan plot for KAZN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KAZN

UniProt ID: Q674X7

Entrez ID: 23254

Protein name: Kazrin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KAZN in