DegronMD

Uniprot ID: Q674X7

Source protein: Kazrin

Source gene: KAZN

Class: DEG_APCC_DBOX_1

Location: 720:728

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9774

ASA_SCORE: 72.6889

COIL: 0.7899

CONS_SCORE: 0.6269

DSS_SCORE: 0.4594

HELIX: 0.0906

FCONS_SCORE: 0.9953

RIG_SCORE: 0.7018

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D737N	TCGA-06-6698	GBM	TCGA	GRLPLGKIG	DEG_APCC_DBOX_1	0.0833
p.D737N	TCGA-CA-6717	COAD	TCGA	GRLPLGKIG	DEG_APCC_DBOX_1	0.0833
p.D737N	DO8264	COAD	ICGC	GRLPLGKIG	DEG_APCC_DBOX_1	0.0833
p.D737N	DO13737	GBM	ICGC	GRLPLGKIG	DEG_APCC_DBOX_1	0.0833
p.D735Y	TCGA-AA-A00N	COAD	TCGA	GRLPLGKIG	DEG_APCC_DBOX_1	0.1389
p.D735Y	DO9876	COAD	ICGC	GRLPLGKIG	DEG_APCC_DBOX_1	0.1389
p.D735Y	ACH-001147	Lymphoma	CCLE	GRLPLGKIG	DEG_APCC_DBOX_1	0.1389
p.P723S	TCGA-DF-A2KU	UCEC	TCGA	GRLPLGKIG	DEG_APCC_DBOX_1	0.5641
p.P723S	DO223286	UCEC	ICGC	GRLPLGKIG	DEG_APCC_DBOX_1	0.5641
p.E710K	TCGA-ER-A194	SKCM	TCGA	GRLPLGKIG	DEG_APCC_DBOX_1	0.0556
p.E710K	DO47646	SKCM	ICGC	GRLPLGKIG	DEG_APCC_DBOX_1	0.0556
p.G730C	DO228974	LICA	ICGC	GRLPLGKIG	DEG_APCC_DBOX_1	0.2778
p.G728V	DO229031	LICA	ICGC	GRLPLGKIG	DEG_APCC_DBOX_1	0.6421
p.A719S	DO229034	LICA	ICGC	GRLPLGKIG	DEG_APCC_DBOX_1	0.3056
p.K716E	DO232861	NACA	ICGC	GRLPLGKIG	DEG_APCC_DBOX_1	0.3333
p.D735E	SIDM00845	Burkitt's Lymphoma	GDSC	GRLPLGKIG	DEG_APCC_DBOX_1	0.1389
p.Y717H	ACH-000990	Endometrial/Uterine Cancer	CCLE	GRLPLGKIG	DEG_APCC_DBOX_1	0.6944
p.G725S	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	GRLPLGKIG	DEG_APCC_DBOX_1	0.5882

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q674X7	Kazrin	DEG_APCC_DBOX_1	720:728	GRLPLGKIG	APC,CDC20,FZR1	0.9774	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons