DegronMD - Q68BL8(OLFML2B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G210C	TCGA-95-7039	LUAD	TCGA	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation altering degron motif	0.6489
p.G210C	DO23907	LUAD	ICGC	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation altering degron motif	0.6489
p.K208T	TCGA-BS-A0TC	UCEC	TCGA	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation rewiring degron network	0.2778
p.K208T	DO42400	UCEC	ICGC	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation rewiring degron network	0.2778
p.I218M	TCGA-DX-A1L0	SARC	TCGA	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation rewiring degron network	0.2222
p.I218M	DO219949	SARC	ICGC	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation rewiring degron network	0.2222
p.R203Q	TCGA-EO-A3AY	UCEC	TCGA	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation rewiring degron network	0.1389
p.R203Q	DO43202	UCEC	ICGC	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation rewiring degron network	0.1389
p.R203Q	SIDM00534	Colorectal Carcinoma	GDSC	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation rewiring degron network	0.1389
p.R203Q	ACH-000986	Colon/Colorectal Cancer	CCLE	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation rewiring degron network	0.1389
p.R203Q	HT-115	large intestine	COSMIC	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation rewiring degron network	0.1389
p.E205K	TCGA-ER-A19K	SKCM	TCGA	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation rewiring degron network	0.1944
p.E205K	DO222884	COCA	ICGC	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation rewiring degron network	0.1944
p.E205K	DO47672	SKCM	ICGC	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation rewiring degron network	0.1944
p.E212D	DO222768	BTCA	ICGC	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation altering degron motif	0.6758
p.D224E	DO229028	LICA	ICGC	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation rewiring degron network	0.0556
p.N217K	DO229037	LICA	ICGC	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation rewiring degron network	0.25
p.E201K	DO220877	MELA	ICGC	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation rewiring degron network	0.0833
p.S221I	DO232761	PBCA	ICGC	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation rewiring degron network	0.1389
p.R203P	SIDM00930	Osteosarcoma	GDSC	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation rewiring degron network	0.1389
p.R203P	ACH-001715	Bone Cancer	CCLE	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation rewiring degron network	0.1389
p.R203P	CAL-72	bone	COSMIC	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation rewiring degron network	0.1389
p.T204N	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation rewiring degron network	0.1667
p.T204N	ACH-000637	Esophageal Cancer	CCLE	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation rewiring degron network	0.1667
p.T204N	KYSE-520	oesophagus	COSMIC	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation rewiring degron network	0.1667
p.T204M	CW-2	large intestine	COSMIC	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation rewiring degron network	0.1667
p.A218V	NCI-H358	lung	COSMIC	GKENC	DEG_APCC_KENBOX_2	210:214	Mutation rewiring degron network	0.2222

Kaplan plot for OLFML2B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OLFML2B

UniProt ID: Q68BL8

Entrez ID: 25903

Protein name: Olfactomedin-like protein 2B (Photomedin-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OLFML2B in