DegronMD

Uniprot ID: Q68BL8

Source protein: Olfactomedin-like protein 2B

Source gene: OLFML2B

Class: DEG_APCC_KENBOX_2

Location: 210:214

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7851

ASA_SCORE: 84.64

COIL: 0.833

CONS_SCORE: 0.6005

DSS_SCORE: 0.5486

HELIX: 0.1154

FCONS_SCORE: 1.0549

RIG_SCORE: 0.6987

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G210C	TCGA-95-7039	LUAD	TCGA	GKENC	DEG_APCC_KENBOX_2	0.6489
p.G210C	DO23907	LUAD	ICGC	GKENC	DEG_APCC_KENBOX_2	0.6489
p.K208T	TCGA-BS-A0TC	UCEC	TCGA	GKENC	DEG_APCC_KENBOX_2	0.2778
p.K208T	DO42400	UCEC	ICGC	GKENC	DEG_APCC_KENBOX_2	0.2778
p.I218M	TCGA-DX-A1L0	SARC	TCGA	GKENC	DEG_APCC_KENBOX_2	0.2222
p.I218M	DO219949	SARC	ICGC	GKENC	DEG_APCC_KENBOX_2	0.2222
p.R203Q	TCGA-EO-A3AY	UCEC	TCGA	GKENC	DEG_APCC_KENBOX_2	0.1389
p.R203Q	DO43202	UCEC	ICGC	GKENC	DEG_APCC_KENBOX_2	0.1389
p.R203Q	SIDM00534	Colorectal Carcinoma	GDSC	GKENC	DEG_APCC_KENBOX_2	0.1389
p.R203Q	ACH-000986	Colon/Colorectal Cancer	CCLE	GKENC	DEG_APCC_KENBOX_2	0.1389
p.R203Q	HT-115	large_intestine	COSMIC	GKENC	DEG_APCC_KENBOX_2	0.1389
p.E205K	TCGA-ER-A19K	SKCM	TCGA	GKENC	DEG_APCC_KENBOX_2	0.1944
p.E205K	DO222884	COCA	ICGC	GKENC	DEG_APCC_KENBOX_2	0.1944
p.E205K	DO47672	SKCM	ICGC	GKENC	DEG_APCC_KENBOX_2	0.1944
p.E212D	DO222768	BTCA	ICGC	GKENC	DEG_APCC_KENBOX_2	0.6758
p.D224E	DO229028	LICA	ICGC	GKENC	DEG_APCC_KENBOX_2	0.0556
p.N217K	DO229037	LICA	ICGC	GKENC	DEG_APCC_KENBOX_2	0.25
p.E201K	DO220877	MELA	ICGC	GKENC	DEG_APCC_KENBOX_2	0.0833
p.S221I	DO232761	PBCA	ICGC	GKENC	DEG_APCC_KENBOX_2	0.1389
p.R203P	SIDM00930	Osteosarcoma	GDSC	GKENC	DEG_APCC_KENBOX_2	0.1389
p.R203P	ACH-001715	Bone Cancer	CCLE	GKENC	DEG_APCC_KENBOX_2	0.1389
p.R203P	CAL-72	bone	COSMIC	GKENC	DEG_APCC_KENBOX_2	0.1389
p.T204N	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	GKENC	DEG_APCC_KENBOX_2	0.1667
p.T204N	ACH-000637	Esophageal Cancer	CCLE	GKENC	DEG_APCC_KENBOX_2	0.1667
p.T204N	KYSE-520	oesophagus	COSMIC	GKENC	DEG_APCC_KENBOX_2	0.1667
p.T204M	CW-2	large_intestine	COSMIC	GKENC	DEG_APCC_KENBOX_2	0.1667
p.A218V	NCI-H358	lung	COSMIC	GKENC	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68BL8	Olfactomedin-like protein 2B	DEG_APCC_KENBOX_2	210:214	GKENC	APC,CDC20,FZR1	0.7851	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GKENC

Degron related mutations and impact score

Drug responses associated with OLFML2B mutations

All proteins holding degron of GKENC