DegronMD - Q68CQ1(MROH7)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T495I	TCGA-44-7670	LUAD	TCGA	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation blocking phosphorylation signal	0.6389
p.E503K	TCGA-EE-A2GM	SKCM	TCGA	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation altering degron motif	0.591
p.R499Q	TCGA-EO-A22R	UCEC	TCGA	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.3056
p.S517Y	TCGA-ER-A19D	SKCM	TCGA	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.0833
p.V507M	TCGA-FI-A2D0	UCEC	TCGA	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation altering degron motif	0.6097
p.S517F	TCGA-FS-A1ZK	SKCM	TCGA	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.0833
p.S517F	TCGA-QB-A6FS	SKCM	TCGA	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.0833
p.R499W	TCGA-VQ-A8P2	STAD	TCGA	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.3056
p.E518Q	DO48439	BLCA	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.0556
p.R514H	DO9202	COAD	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.1667
p.R514H	DO38851	STAD	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.1667
p.R515Q	DO10132	COAD	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.1389
p.R515Q	DO50159	LGG	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.1389
p.A502S	DO228971	LICA	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation altering degron motif	0.7588
p.A502S	DO229015	LICA	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation altering degron motif	0.7588
p.D493Y	DO229041	LICA	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.1389
p.R514L	DO229045	LICA	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.1667
p.R514L	DO45485	LUSC	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.1667
p.E490Q	DO24910	LUAD	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation blocking phosphorylation signal	0.5
p.R491Q	DO220851	MELA	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.0833
p.D493N	DO35206	PACA	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.1389
p.P517H	DO37782	SKCM	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.0833
p.L508F	DO51299	SKCM	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation altering degron motif	0.6981
p.A502T	DO229232	THCA	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation altering degron motif	0.7139
p.R497G	DO42023	UCEC	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.25
p.K495N	DO41235	UCEC	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation blocking phosphorylation signal	0.6389
p.R515W	DO43891	UCEC	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.1389
p.A500T	DO41331	UCEC	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation altering degron motif	0.7139
p.V505M	DO229547	UTCA	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation altering degron motif	0.6097
p.V512M	SIDM00650	Small Cell Lung Carcinoma	GDSC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.2222
p.V512M	SIDM00971	Breast Carcinoma	GDSC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.2222
p.V512M	SIDM01681	Non-Cancerous	GDSC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.2222
p.V509G	SIDM00612	Glioma	GDSC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.3056
p.V509G	SIDM00531	Pancreatic Carcinoma	GDSC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.3056
p.V509G	KINGS-1	central nervous system	COSMIC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.3056
p.V509G	HuP-T4	pancreas	COSMIC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.3056
p.S502L	SIDM01611	Endometrial Carcinoma	GDSC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation altering degron motif	0.6556
p.S502L	ACH-000996	Endometrial/Uterine Cancer	CCLE	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation altering degron motif	0.6556
p.T492M	KP-4	pancreas	COSMIC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.1111
p.G512V	COR-L303	lung	COSMIC	ERSELVNVC	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MROH7

UniProt ID: Q68CQ1

Entrez ID: 374977

Protein name: Maestro heat-like repeat-containing protein family member 7 (HEAT repeat-containing protein 8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MROH7 in