DegronMD

Uniprot ID: Q68CQ1

Source protein: Maestro heat-like repeat-containing protein family member 7

Source gene: MROH7

Class: DEG_APCC_DBOX_1

Location: 500:508

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.593

ASA_SCORE: 35.3333

COIL: 0.0086

CONS_SCORE: 0.4349

DSS_SCORE: 0.2672

HELIX: 0.9911

FCONS_SCORE: 1.0127

RIG_SCORE: 0.7885

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T495I	TCGA-44-7670	LUAD	TCGA	ERSELVNVC	DEG_APCC_DBOX_1	0.6389
p.E503K	TCGA-EE-A2GM	SKCM	TCGA	ERSELVNVC	DEG_APCC_DBOX_1	0.591
p.R499Q	TCGA-EO-A22R	UCEC	TCGA	ERSELVNVC	DEG_APCC_DBOX_1	0.3056
p.S517Y	TCGA-ER-A19D	SKCM	TCGA	ERSELVNVC	DEG_APCC_DBOX_1	0.0833
p.V507M	TCGA-FI-A2D0	UCEC	TCGA	ERSELVNVC	DEG_APCC_DBOX_1	0.6097
p.S517F	TCGA-FS-A1ZK	SKCM	TCGA	ERSELVNVC	DEG_APCC_DBOX_1	0.0833
p.S517F	TCGA-QB-A6FS	SKCM	TCGA	ERSELVNVC	DEG_APCC_DBOX_1	0.0833
p.R499W	TCGA-VQ-A8P2	STAD	TCGA	ERSELVNVC	DEG_APCC_DBOX_1	0.3056
p.E518Q	DO48439	BLCA	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	0.0556
p.R514H	DO9202	COAD	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	0.1667
p.R514H	DO38851	STAD	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	0.1667
p.R515Q	DO10132	COAD	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	0.1389
p.R515Q	DO50159	LGG	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	0.1389
p.A502S	DO228971	LICA	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	0.7588
p.A502S	DO229015	LICA	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	0.7588
p.D493Y	DO229041	LICA	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	0.1389
p.R514L	DO229045	LICA	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	0.1667
p.R514L	DO45485	LUSC	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	0.1667
p.E490Q	DO24910	LUAD	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	0.5
p.R491Q	DO220851	MELA	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	0.0833
p.D493N	DO35206	PACA	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	0.1389
p.P517H	DO37782	SKCM	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	0.0833
p.L508F	DO51299	SKCM	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	0.6981
p.A502T	DO229232	THCA	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	0.7139
p.R497G	DO42023	UCEC	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	0.25
p.K495N	DO41235	UCEC	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	0.6389
p.R515W	DO43891	UCEC	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	0.1389
p.A500T	DO41331	UCEC	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	0.7139
p.V505M	DO229547	UTCA	ICGC	ERSELVNVC	DEG_APCC_DBOX_1	0.6097
p.V512M	SIDM00650	Small Cell Lung Carcinoma	GDSC	ERSELVNVC	DEG_APCC_DBOX_1	0.2222
p.V512M	SIDM00971	Breast Carcinoma	GDSC	ERSELVNVC	DEG_APCC_DBOX_1	0.2222
p.V512M	SIDM01681	Non-Cancerous	GDSC	ERSELVNVC	DEG_APCC_DBOX_1	0.2222
p.V509G	SIDM00612	Glioma	GDSC	ERSELVNVC	DEG_APCC_DBOX_1	0.3056
p.V509G	SIDM00531	Pancreatic Carcinoma	GDSC	ERSELVNVC	DEG_APCC_DBOX_1	0.3056
p.V509G	KINGS-1	central_nervous_system	COSMIC	ERSELVNVC	DEG_APCC_DBOX_1	0.3056
p.V509G	HuP-T4	pancreas	COSMIC	ERSELVNVC	DEG_APCC_DBOX_1	0.3056
p.S502L	SIDM01611	Endometrial Carcinoma	GDSC	ERSELVNVC	DEG_APCC_DBOX_1	0.6556
p.S502L	ACH-000996	Endometrial/Uterine Cancer	CCLE	ERSELVNVC	DEG_APCC_DBOX_1	0.6556
p.T492M	KP-4	pancreas	COSMIC	ERSELVNVC	DEG_APCC_DBOX_1	0.1111
p.G512V	COR-L303	lung	COSMIC	ERSELVNVC	DEG_APCC_DBOX_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERSELVNVC

Degron related mutations and impact score

Drug responses associated with MROH7 mutations

All proteins holding degron of ERSELVNVC

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68CQ1	Maestro heat-like repeat-containing protein family member 7	DEG_APCC_DBOX_1	500:508	ERSELVNVC	APC,CDC20,FZR1	0.593	More...