DegronMD - Q68D86(CCDC102B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I345V	TCGA-2W-A8YY	CESC	TCGA	LRAELERLQ	DEG_APCC_DBOX_1	348:356	Mutation rewiring degron network	0.25
p.I345V	DO223732	CESC	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	348:356	Mutation rewiring degron network	0.25
p.W363L	TCGA-44-8117	LUAD	TCGA	LRAELERLQ	DEG_APCC_DBOX_1	348:356	Mutation rewiring degron network	0.1389
p.W363L	DO24028	LUAD	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	348:356	Mutation rewiring degron network	0.1389
p.D364H	TCGA-77-A5G3	LUSC	TCGA	LRAELERLQ	DEG_APCC_DBOX_1	348:356	Mutation rewiring degron network	0.1111
p.D364H	DO45456	LUSC	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	348:356	Mutation rewiring degron network	0.1111
p.R366K	TCGA-77-A5GA	LUSC	TCGA	LRAELERLQ	DEG_APCC_DBOX_1	348:356	Mutation rewiring degron network	0.0556
p.R366K	DO50100	LUSC	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	348:356	Mutation rewiring degron network	0.0556
p.E351D	TCGA-BA-A6DA	HNSC	TCGA	LRAELERLQ	DEG_APCC_DBOX_1	348:356	Mutation altering degron motif	0.5647
p.E351D	DO44448	HNSC	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	348:356	Mutation altering degron motif	0.5647
p.D342N	TCGA-CN-4729	HNSC	TCGA	LRAELERLQ	DEG_APCC_DBOX_1	348:356	Mutation rewiring degron network	0.1667
p.D342N	DO16029	HNSC	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	348:356	Mutation rewiring degron network	0.1667
p.R366M	TCGA-CN-4729	HNSC	TCGA	LRAELERLQ	DEG_APCC_DBOX_1	348:356	Mutation rewiring degron network	0.0556
p.R366M	DO16029	HNSC	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	348:356	Mutation rewiring degron network	0.0556
p.R366M	DO228948	LICA	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	348:356	Mutation rewiring degron network	0.0556
p.V344G	TCGA-ER-A19D	SKCM	TCGA	LRAELERLQ	DEG_APCC_DBOX_1	348:356	Mutation rewiring degron network	0.2222
p.V344G	DO37750	SKCM	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	348:356	Mutation rewiring degron network	0.2222
p.A357T	TCGA-NK-A5D1	LUSC	TCGA	LRAELERLQ	DEG_APCC_DBOX_1	348:356	Mutation rewiring degron network	0.3056
p.A357T	DO219213	LUSC	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	348:356	Mutation rewiring degron network	0.3056
p.D342Y	TCGA-QF-A5YS	UCEC	TCGA	LRAELERLQ	DEG_APCC_DBOX_1	348:356	Mutation rewiring degron network	0.1667
p.D342Y	DO52426	UCEC	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	348:356	Mutation rewiring degron network	0.1667
p.C346F	DO230334	COCA	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	348:356	Mutation rewiring degron network	0.2778
p.C346F	DO234285	ESAD	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	348:356	Mutation rewiring degron network	0.2778
p.R354K	DO229453	SKCA	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	348:356	Mutation altering degron motif	0.6126
p.E358K	SIDM00220	Ovarian Carcinoma	GDSC	LRAELERLQ	DEG_APCC_DBOX_1	348:356	Mutation rewiring degron network	0.2778
p.E353K	ACH-001573	Leukemia	CCLE	LRAELERLQ	DEG_APCC_DBOX_1	348:356	Mutation altering degron motif	0.591

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC102B

UniProt ID: Q68D86

Entrez ID: 79839

Protein name: Coiled-coil domain-containing protein 102B

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC102B in