DegronMD

Uniprot ID: Q68D86

Source protein: Coiled-coil domain-containing protein 102B

Source gene: CCDC102B

Class: DEG_APCC_DBOX_1

Location: 348:356

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7877

ASA_SCORE: 98.1889

COIL: 0.0303

CONS_SCORE: 0.5814

DSS_SCORE: 0.3439

HELIX: 0.9706

FCONS_SCORE: 1.2126

RIG_SCORE: 0.7996

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I345V	TCGA-2W-A8YY	CESC	TCGA	LRAELERLQ	DEG_APCC_DBOX_1	0.25
p.I345V	DO223732	CESC	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	0.25
p.W363L	TCGA-44-8117	LUAD	TCGA	LRAELERLQ	DEG_APCC_DBOX_1	0.1389
p.W363L	DO24028	LUAD	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	0.1389
p.D364H	TCGA-77-A5G3	LUSC	TCGA	LRAELERLQ	DEG_APCC_DBOX_1	0.1111
p.D364H	DO45456	LUSC	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	0.1111
p.R366K	TCGA-77-A5GA	LUSC	TCGA	LRAELERLQ	DEG_APCC_DBOX_1	0.0556
p.R366K	DO50100	LUSC	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	0.0556
p.E351D	TCGA-BA-A6DA	HNSC	TCGA	LRAELERLQ	DEG_APCC_DBOX_1	0.5647
p.E351D	DO44448	HNSC	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	0.5647
p.D342N	TCGA-CN-4729	HNSC	TCGA	LRAELERLQ	DEG_APCC_DBOX_1	0.1667
p.D342N	DO16029	HNSC	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	0.1667
p.R366M	TCGA-CN-4729	HNSC	TCGA	LRAELERLQ	DEG_APCC_DBOX_1	0.0556
p.R366M	DO16029	HNSC	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	0.0556
p.R366M	DO228948	LICA	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	0.0556
p.V344G	TCGA-ER-A19D	SKCM	TCGA	LRAELERLQ	DEG_APCC_DBOX_1	0.2222
p.V344G	DO37750	SKCM	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	0.2222
p.A357T	TCGA-NK-A5D1	LUSC	TCGA	LRAELERLQ	DEG_APCC_DBOX_1	0.3056
p.A357T	DO219213	LUSC	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	0.3056
p.D342Y	TCGA-QF-A5YS	UCEC	TCGA	LRAELERLQ	DEG_APCC_DBOX_1	0.1667
p.D342Y	DO52426	UCEC	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	0.1667
p.C346F	DO230334	COCA	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	0.2778
p.C346F	DO234285	ESAD	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	0.2778
p.R354K	DO229453	SKCA	ICGC	LRAELERLQ	DEG_APCC_DBOX_1	0.6126
p.E358K	SIDM00220	Ovarian Carcinoma	GDSC	LRAELERLQ	DEG_APCC_DBOX_1	0.2778
p.E353K	ACH-001573	Leukemia	CCLE	LRAELERLQ	DEG_APCC_DBOX_1	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68D86	Coiled-coil domain-containing protein 102B	DEG_APCC_DBOX_1	348:356	LRAELERLQ	APC,CDC20,FZR1	0.7877	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRAELERLQ

Degron related mutations and impact score

Drug responses associated with CCDC102B mutations

All proteins holding degron of LRAELERLQ