DegronMD - Q68DC2(ANKS6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S764C	TCGA-66-2787	LUSC	TCGA	VSSSS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.1111
p.P735A	SIDM01963	Colorectal Carcinoma	GDSC	PTLTPSPS	DEG_SCF_FBW7_1	735:742	Mutation altering degron motif	0.7503
p.P735A	SIDM00969	Ovarian Carcinoma	GDSC	PTLTPSPS	DEG_SCF_FBW7_1	735:742	Mutation altering degron motif	0.7503
p.P735A	SIDM01039	Other Solid Cancers	GDSC	PTLTPSPS	DEG_SCF_FBW7_1	735:742	Mutation altering degron motif	0.7503
p.P735A	SIDM00793	Burkitt's Lymphoma	GDSC	PTLTPSPS	DEG_SCF_FBW7_1	735:742	Mutation altering degron motif	0.7503
p.P735A	SIDM00954	Breast Carcinoma	GDSC	PTLTPSPS	DEG_SCF_FBW7_1	735:742	Mutation altering degron motif	0.7503
p.P735A	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PTLTPSPS	DEG_SCF_FBW7_1	735:742	Mutation altering degron motif	0.7503
p.G745R	SIDM00884	Breast Carcinoma	GDSC	PTLTPSPS	DEG_SCF_FBW7_1	735:742	Mutation rewiring degron network	0.25
p.G745R	SIDM00884	Breast Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.1389
p.G745R	SIDM00883	Non-Cancerous	GDSC	PTLTPSPS	DEG_SCF_FBW7_1	735:742	Mutation rewiring degron network	0.25
p.G745R	SIDM00883	Non-Cancerous	GDSC	VSSSS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.1389
p.Q760L	SIDM01119	Other Solid Cancers	GDSC	VSSSS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.2222
p.Q760L	NCI-H727	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.2222
p.S757F	SIDM01175	Other Sarcomas	GDSC	VSSSS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.3056
p.S757F	SW684	soft tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.3056
p.R759W	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.25
p.R759Q	SIDM01686	Chronic Myelogenous Leukemia	GDSC	VSSSS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.25
p.S753F	SIDM01578	Bladder Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	752:756	Mutation altering degron motif	0.6871

Kaplan plot for ANKS6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKS6

UniProt ID: Q68DC2

Entrez ID: 203286

Protein name: Ankyrin repeat and SAM domain-containing protein 6 (Ankyrin repeat domain-containing protein 14) (SamCystin) (Sterile alpha motif domain-containing protein 6) (SAM domain-containing protein 6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANKS6 in