DegronMD

Uniprot ID: Q68DC2

Source protein: Ankyrin repeat and SAM domain-containing protein 6

Source gene: ANKS6

Class: DEG_SCF_FBW7_1

Location: 735:742

E3 ligase: FBXW7

DEGRON score: 0.9281

ASA_SCORE: 89

COIL: 0.9699

CONS_SCORE: 0.4804

DSS_SCORE: 0.7518

HELIX: 0.0086

FCONS_SCORE: 0.9396

RIG_SCORE: 0.53

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P735A	SIDM01963	Colorectal Carcinoma	GDSC	PTLTPSPS	DEG_SCF_FBW7_1	0.7503
p.P735A	SIDM00969	Ovarian Carcinoma	GDSC	PTLTPSPS	DEG_SCF_FBW7_1	0.7503
p.P735A	SIDM01039	Other Solid Cancers	GDSC	PTLTPSPS	DEG_SCF_FBW7_1	0.7503
p.P735A	SIDM00793	Burkitt's Lymphoma	GDSC	PTLTPSPS	DEG_SCF_FBW7_1	0.7503
p.P735A	SIDM00954	Breast Carcinoma	GDSC	PTLTPSPS	DEG_SCF_FBW7_1	0.7503
p.P735A	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PTLTPSPS	DEG_SCF_FBW7_1	0.7503
p.G745R	SIDM00884	Breast Carcinoma	GDSC	PTLTPSPS	DEG_SCF_FBW7_1	0.25
p.G745R	SIDM00883	Non-Cancerous	GDSC	PTLTPSPS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68DC2	Ankyrin repeat and SAM domain-containing protein 6	DEG_SCF_FBW7_1	735:742	PTLTPSPS	FBXW7	0.9281	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons