DegronMD - Q68DH5(LMBRD2)

LMBRD2

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D690N	TCGA-34-5232	LUSC	TCGA	RSDIFND	LIG_APCC_ABBAyCdc20_2	688:694	Mutation altering degron motif	0.5821
p.D690N	DO27168	LUSC	ICGC	RSDIFND	LIG_APCC_ABBAyCdc20_2	688:694	Mutation altering degron motif	0.5821
p.S685L	TCGA-AA-3877	COAD	TCGA	RSDIFND	LIG_APCC_ABBAyCdc20_2	688:694	Mutation blocking phosphorylation signal	0.6944
p.S685L	TCGA-EO-A22U	UCEC	TCGA	RSDIFND	LIG_APCC_ABBAyCdc20_2	688:694	Mutation blocking phosphorylation signal	0.6944
p.S685L	DO7855	COAD	ICGC	RSDIFND	LIG_APCC_ABBAyCdc20_2	688:694	Mutation blocking phosphorylation signal	0.6944
p.S685L	DO43755	UCEC	ICGC	RSDIFND	LIG_APCC_ABBAyCdc20_2	688:694	Mutation blocking phosphorylation signal	0.6944
p.S685L	SIDM00193	Colorectal Carcinoma	GDSC	RSDIFND	LIG_APCC_ABBAyCdc20_2	688:694	Mutation blocking phosphorylation signal	0.6944
p.S685L	ACH-000991	Colon/Colorectal Cancer	CCLE	RSDIFND	LIG_APCC_ABBAyCdc20_2	688:694	Mutation blocking phosphorylation signal	0.6944
p.S685L	SNU-81	large intestine	COSMIC	RSDIFND	LIG_APCC_ABBAyCdc20_2	688:694	Mutation blocking phosphorylation signal	0.6944
p.D694N	DO234193	ESAD	ICGC	RSDIFND	LIG_APCC_ABBAyCdc20_2	688:694	Mutation altering degron motif	0.6932
p.R688H	DO233804	GACA	ICGC	RSDIFND	LIG_APCC_ABBAyCdc20_2	688:694	Mutation altering degron motif	0.8244
p.R682L	DO229032	LICA	ICGC	RSDIFND	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.1667
p.G680D	DO51537	PACA	ICGC	RSDIFND	LIG_APCC_ABBAyCdc20_2	688:694	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc