DegronMD

Uniprot ID: Q68DH5

Source protein: G-protein coupled receptor-associated protein LMBRD2

Source gene: LMBRD2

Class: LIG_APCC_ABBAyCdc20_2

Location: 688:694

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9991

ASA_SCORE: 76.9143

COIL: 0.8044

CONS_SCORE: 0.3388

DSS_SCORE: 0.6822

HELIX: 0.1357

FCONS_SCORE: 1.1432

RIG_SCORE: 0.7628

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D690N	TCGA-34-5232	LUSC	TCGA	RSDIFND	LIG_APCC_ABBAyCdc20_2	0.5821
p.D690N	DO27168	LUSC	ICGC	RSDIFND	LIG_APCC_ABBAyCdc20_2	0.5821
p.S685L	TCGA-AA-3877	COAD	TCGA	RSDIFND	LIG_APCC_ABBAyCdc20_2	0.6944
p.S685L	TCGA-EO-A22U	UCEC	TCGA	RSDIFND	LIG_APCC_ABBAyCdc20_2	0.6944
p.S685L	DO7855	COAD	ICGC	RSDIFND	LIG_APCC_ABBAyCdc20_2	0.6944
p.S685L	DO43755	UCEC	ICGC	RSDIFND	LIG_APCC_ABBAyCdc20_2	0.6944
p.S685L	SIDM00193	Colorectal Carcinoma	GDSC	RSDIFND	LIG_APCC_ABBAyCdc20_2	0.6944
p.S685L	ACH-000991	Colon/Colorectal Cancer	CCLE	RSDIFND	LIG_APCC_ABBAyCdc20_2	0.6944
p.S685L	SNU-81	large_intestine	COSMIC	RSDIFND	LIG_APCC_ABBAyCdc20_2	0.6944
p.D694N	DO234193	ESAD	ICGC	RSDIFND	LIG_APCC_ABBAyCdc20_2	0.6932
p.R688H	DO233804	GACA	ICGC	RSDIFND	LIG_APCC_ABBAyCdc20_2	0.8244
p.R682L	DO229032	LICA	ICGC	RSDIFND	LIG_APCC_ABBAyCdc20_2	0.1667
p.G680D	DO51537	PACA	ICGC	RSDIFND	LIG_APCC_ABBAyCdc20_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68DH5	G-protein coupled receptor-associated protein LMBRD2	LIG_APCC_ABBAyCdc20_2	688:694	RSDIFND	APC,CDC20,FZR1	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons