DegronMD - Q68DX3(FRMPD2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P938L	TCGA-AR-A256	BRCA	TCGA	LRHQLSFLP	DEG_APCC_DBOX_1	920:928	Mutation rewiring degron network	0.0556
p.P928L	TCGA-AZ-4315	COAD	TCGA	LRHQLSFLP	DEG_APCC_DBOX_1	920:928	Mutation altering degron motif	0.6471
p.R919M	TCGA-B5-A3FA	UCEC	TCGA	LRHQLSFLP	DEG_APCC_DBOX_1	920:928	Mutation rewiring degron network	0.3056
p.E910K	DO1285	BRCA	ICGC	LRHQLSFLP	DEG_APCC_DBOX_1	920:928	Mutation rewiring degron network	0.0556
p.I911V	DO234300	ESAD	ICGC	LRHQLSFLP	DEG_APCC_DBOX_1	920:928	Mutation rewiring degron network	0.0833
p.I936V	DO51016	LAML	ICGC	LRHQLSFLP	DEG_APCC_DBOX_1	920:928	Mutation rewiring degron network	0.1111
p.I936V	DO229006	LICA	ICGC	LRHQLSFLP	DEG_APCC_DBOX_1	920:928	Mutation rewiring degron network	0.1111
p.I936V	DO219878	SKCA	ICGC	LRHQLSFLP	DEG_APCC_DBOX_1	920:928	Mutation rewiring degron network	0.1111
p.T927K	DO228952	LICA	ICGC	LRHQLSFLP	DEG_APCC_DBOX_1	920:928	Mutation altering degron motif	0.7306
p.E915K	DO222753	MELA	ICGC	LRHQLSFLP	DEG_APCC_DBOX_1	920:928	Mutation rewiring degron network	0.1944
p.E915K	DO222775	MELA	ICGC	LRHQLSFLP	DEG_APCC_DBOX_1	920:928	Mutation rewiring degron network	0.1944
p.E915K	DO47665	SKCM	ICGC	LRHQLSFLP	DEG_APCC_DBOX_1	920:928	Mutation rewiring degron network	0.1944
p.E920K	DO222908	MELA	ICGC	LRHQLSFLP	DEG_APCC_DBOX_1	920:928	Mutation altering degron motif	0.7022
p.E924K	DO37447	SKCM	ICGC	LRHQLSFLP	DEG_APCC_DBOX_1	920:928	Mutation altering degron motif	0.7022
p.G929V	DO42496	UCEC	ICGC	LRHQLSFLP	DEG_APCC_DBOX_1	920:928	Mutation rewiring degron network	0.3056
p.S934Y	SIDM00625	Other Sarcomas	GDSC	LRHQLSFLP	DEG_APCC_DBOX_1	920:928	Mutation blocking phosphorylation signal	0.6111
p.C936S	SIDM00162	Biliary Tract Carcinoma	GDSC	LRHQLSFLP	DEG_APCC_DBOX_1	920:928	Mutation rewiring degron network	0.1111
p.S935F	ACH-000047	Gastric Cancer	CCLE	LRHQLSFLP	DEG_APCC_DBOX_1	920:928	Mutation rewiring degron network	0.1389
p.S934F	ACH-000900	Lung Cancer	CCLE	LRHQLSFLP	DEG_APCC_DBOX_1	920:928	Mutation blocking phosphorylation signal	0.6111

Kaplan plot for FRMPD2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FRMPD2

UniProt ID: Q68DX3

Entrez ID: 143162

Protein name: FERM and PDZ domain-containing protein 2 (PDZ domain-containing protein 4) (PDZ domain-containing protein 5C)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FRMPD2 in