DegronMD

Uniprot ID: Q68DX3

Source protein: FERM and PDZ domain-containing protein 2

Source gene: FRMPD2

Class: DEG_APCC_DBOX_1

Location: 920:928

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9225

ASA_SCORE: 94.9889

COIL: 0.7302

CONS_SCORE: 1

DSS_SCORE: 0.3345

HELIX: 0.1843

FCONS_SCORE: 1.0556

RIG_SCORE: 0.7715

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P938L	TCGA-AR-A256	BRCA	TCGA	LRHQLSFLP	DEG_APCC_DBOX_1	0.0556
p.P928L	TCGA-AZ-4315	COAD	TCGA	LRHQLSFLP	DEG_APCC_DBOX_1	0.6471
p.R919M	TCGA-B5-A3FA	UCEC	TCGA	LRHQLSFLP	DEG_APCC_DBOX_1	0.3056
p.E910K	DO1285	BRCA	ICGC	LRHQLSFLP	DEG_APCC_DBOX_1	0.0556
p.I911V	DO234300	ESAD	ICGC	LRHQLSFLP	DEG_APCC_DBOX_1	0.0833
p.I936V	DO51016	LAML	ICGC	LRHQLSFLP	DEG_APCC_DBOX_1	0.1111
p.I936V	DO229006	LICA	ICGC	LRHQLSFLP	DEG_APCC_DBOX_1	0.1111
p.I936V	DO219878	SKCA	ICGC	LRHQLSFLP	DEG_APCC_DBOX_1	0.1111
p.T927K	DO228952	LICA	ICGC	LRHQLSFLP	DEG_APCC_DBOX_1	0.7306
p.E915K	DO222753	MELA	ICGC	LRHQLSFLP	DEG_APCC_DBOX_1	0.1944
p.E915K	DO222775	MELA	ICGC	LRHQLSFLP	DEG_APCC_DBOX_1	0.1944
p.E915K	DO47665	SKCM	ICGC	LRHQLSFLP	DEG_APCC_DBOX_1	0.1944
p.E920K	DO222908	MELA	ICGC	LRHQLSFLP	DEG_APCC_DBOX_1	0.7022
p.E924K	DO37447	SKCM	ICGC	LRHQLSFLP	DEG_APCC_DBOX_1	0.7022
p.G929V	DO42496	UCEC	ICGC	LRHQLSFLP	DEG_APCC_DBOX_1	0.3056
p.S934Y	SIDM00625	Other Sarcomas	GDSC	LRHQLSFLP	DEG_APCC_DBOX_1	0.6111
p.C936S	SIDM00162	Biliary Tract Carcinoma	GDSC	LRHQLSFLP	DEG_APCC_DBOX_1	0.1111
p.S935F	ACH-000047	Gastric Cancer	CCLE	LRHQLSFLP	DEG_APCC_DBOX_1	0.1389
p.S934F	ACH-000900	Lung Cancer	CCLE	LRHQLSFLP	DEG_APCC_DBOX_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68DX3	FERM and PDZ domain-containing protein 2	DEG_APCC_DBOX_1	920:928	LRHQLSFLP	APC,CDC20,FZR1	0.9225	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons