DegronMD - Q68E01(INTS3)

INTS3

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D572H	TCGA-22-5474	LUSC	TCGA	ITPYLD	LIG_APCC_ABBA_1	568:573	Mutation altering degron motif	0.7688
p.P564S	TCGA-A5-A0G2	UCEC	TCGA	ITPYLD	LIG_APCC_ABBA_1	568:573	Mutation rewiring degron network	0.2222
p.L578M	TCGA-AP-A051	UCEC	TCGA	ITPYLD	LIG_APCC_ABBA_1	568:573	Mutation blocking phosphorylation signal	0.6389
p.L578M	SIDM01617	Endometrial Carcinoma	GDSC	ITPYLD	LIG_APCC_ABBA_1	568:573	Mutation blocking phosphorylation signal	0.6389
p.L578M	ACH-000994	Endometrial/Uterine Cancer	CCLE	ITPYLD	LIG_APCC_ABBA_1	568:573	Mutation blocking phosphorylation signal	0.6389
p.D572Y	TCGA-AP-A0LM	UCEC	TCGA	ITPYLD	LIG_APCC_ABBA_1	568:573	Mutation altering degron motif	0.7325
p.T568A	TCGA-D1-A163	UCEC	TCGA	ITPYLD	LIG_APCC_ABBA_1	568:573	Mutation altering degron motif	0.7139
p.S577F	TCGA-D3-A8GK	SKCM	TCGA	ITPYLD	LIG_APCC_ABBA_1	568:573	Mutation rewiring degron network	0.2222
p.Q567R	DO49680	LIAD	ICGC	ITPYLD	LIG_APCC_ABBA_1	568:573	Mutation rewiring degron network	0.3056
p.E568K	DO229221	THCA	ICGC	ITPYLD	LIG_APCC_ABBA_1	568:573	Mutation altering degron motif	0.7022
p.D572N	SIDM00643	Non-Cancerous	GDSC	ITPYLD	LIG_APCC_ABBA_1	568:573	Mutation altering degron motif	0.6932
p.L571F	SIDM00516	Melanoma	GDSC	ITPYLD	LIG_APCC_ABBA_1	568:573	Mutation altering degron motif	0.6981
p.L571F	ACH-002166	Skin Cancer	CCLE	ITPYLD	LIG_APCC_ABBA_1	568:573	Mutation altering degron motif	0.6981
p.L571F	MZ7-mel	skin	COSMIC	ITPYLD	LIG_APCC_ABBA_1	568:573	Mutation altering degron motif	0.6981

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*NOTE: the Kaplan plots were collected from OncoLnc