DegronMD

Uniprot ID: Q68E01

Source protein: Integrator complex subunit 3

Source gene: INTS3

Class: LIG_APCC_ABBA_1

Location: 568:573

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7417

ASA_SCORE: 64.45

COIL: 0.5305

CONS_SCORE: 0.4316

DSS_SCORE: 0.3979

HELIX: 0.449

FCONS_SCORE: 1.0694

RIG_SCORE: 0.8495

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D572H	TCGA-22-5474	LUSC	TCGA	ITPYLD	LIG_APCC_ABBA_1	0.7688
p.P564S	TCGA-A5-A0G2	UCEC	TCGA	ITPYLD	LIG_APCC_ABBA_1	0.2222
p.L578M	TCGA-AP-A051	UCEC	TCGA	ITPYLD	LIG_APCC_ABBA_1	0.6389
p.L578M	SIDM01617	Endometrial Carcinoma	GDSC	ITPYLD	LIG_APCC_ABBA_1	0.6389
p.L578M	ACH-000994	Endometrial/Uterine Cancer	CCLE	ITPYLD	LIG_APCC_ABBA_1	0.6389
p.D572Y	TCGA-AP-A0LM	UCEC	TCGA	ITPYLD	LIG_APCC_ABBA_1	0.7325
p.T568A	TCGA-D1-A163	UCEC	TCGA	ITPYLD	LIG_APCC_ABBA_1	0.7139
p.S577F	TCGA-D3-A8GK	SKCM	TCGA	ITPYLD	LIG_APCC_ABBA_1	0.2222
p.Q567R	DO49680	LIAD	ICGC	ITPYLD	LIG_APCC_ABBA_1	0.3056
p.E568K	DO229221	THCA	ICGC	ITPYLD	LIG_APCC_ABBA_1	0.7022
p.D572N	SIDM00643	Non-Cancerous	GDSC	ITPYLD	LIG_APCC_ABBA_1	0.6932
p.L571F	SIDM00516	Melanoma	GDSC	ITPYLD	LIG_APCC_ABBA_1	0.6981
p.L571F	ACH-002166	Skin Cancer	CCLE	ITPYLD	LIG_APCC_ABBA_1	0.6981
p.L571F	MZ7-mel	skin	COSMIC	ITPYLD	LIG_APCC_ABBA_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68E01	Integrator complex subunit 3	LIG_APCC_ABBA_1	568:573	ITPYLD	APC,CDC20,FZR1	0.7417	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons