DegronMD - Q69YN2(CWF19L1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S127I	TCGA-19-5956	GBM	TCGA	NEPVPGYSFSP	CBL_PTK	120:130	Mutation altering degron motif	0.7341
p.S127I	DO13863	GBM	ICGC	NEPVPGYSFSP	CBL_PTK	120:130	Mutation altering degron motif	0.7341
p.G125C	TCGA-AP-A059	UCEC	TCGA	NEPVPGYSFSP	CBL_PTK	120:130	Mutation altering degron motif	0.6489
p.G125C	DO41361	UCEC	ICGC	NEPVPGYSFSP	CBL_PTK	120:130	Mutation altering degron motif	0.6489
p.E121K	TCGA-B5-A3FC	UCEC	TCGA	NEPVPGYSFSP	CBL_PTK	120:130	Mutation altering degron motif	0.591
p.E121K	DO41871	UCEC	ICGC	NEPVPGYSFSP	CBL_PTK	120:130	Mutation altering degron motif	0.591
p.K131R	TCGA-F5-6814	READ	TCGA	NEPVPGYSFSP	CBL_PTK	120:130	Mutation rewiring degron network	0.3056
p.K131R	DO36556	READ	ICGC	NEPVPGYSFSP	CBL_PTK	120:130	Mutation rewiring degron network	0.3056
p.E135D	DO44090	COAD	ICGC	NEPVPGYSFSP	CBL_PTK	120:130	Mutation rewiring degron network	0.1944
p.G124E	DO14228	HNSC	ICGC	NEPVPGYSFSP	CBL_PTK	120:130	Mutation altering degron motif	0.7199
p.L121P	DO48732	LIRI	ICGC	NEPVPGYSFSP	CBL_PTK	120:130	Mutation altering degron motif	0.7582
p.P130S	DO222868	MELA	ICGC	NEPVPGYSFSP	CBL_PTK	120:130	Mutation altering degron motif	0.6752
p.S134P	DO232224	PBCA	ICGC	NEPVPGYSFSP	CBL_PTK	120:130	Mutation rewiring degron network	0.2222
p.Y126C	DO41758	UCEC	ICGC	NEPVPGYSFSP	CBL_PTK	120:130	Mutation altering degron motif	0.7087
p.P130R	SIDM01112	Osteosarcoma	GDSC	NEPVPGYSFSP	CBL_PTK	120:130	Mutation altering degron motif	0.7512
p.P130R	ACH-000748	Bone Cancer	CCLE	NEPVPGYSFSP	CBL_PTK	120:130	Mutation altering degron motif	0.7512
p.P130R	SJSA-1	bone	COSMIC	NEPVPGYSFSP	CBL_PTK	120:130	Mutation altering degron motif	0.7512
p.T116K	SIDM01700	Hodgkin's Lymphoma	GDSC	NEPVPGYSFSP	CBL_PTK	120:130	Mutation rewiring degron network	0.2222
p.T116K	ACH-000165	Non-Cancerous	CCLE	NEPVPGYSFSP	CBL_PTK	120:130	Mutation rewiring degron network	0.2222
p.V130A	ACH-001610	Brain Cancer	CCLE	NEPVPGYSFSP	CBL_PTK	120:130	Mutation altering degron motif	0.6936
p.H125Y	ACH-002029	Head and Neck Cancer	CCLE	NEPVPGYSFSP	CBL_PTK	120:130	Mutation altering degron motif	0.7229

Kaplan plot for CWF19L1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CWF19L1

UniProt ID: Q69YN2

Entrez ID: 55280

Protein name: CWF19-like protein 1 (C19L1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CWF19L1 in