DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NEPVPGYSFSP
Uniprot ID:
Q69YN2
Source protein:
CWF19-like protein 1
Source gene:
CWF19L1
Class:
CBL_PTK
Location:
120:130
E3 ligase:
CBL
DEGRON score:
0.5031
ASA_SCORE:
60.6182
COIL:
0.8314
CONS_SCORE:
0.3192
DSS_SCORE:
0.3342
HELIX:
0.0606
FCONS_SCORE:
0.8119
RIG_SCORE:
0.7259
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S127I
TCGA-19-5956
GBM
TCGA
NEPVPGYSFSP
CBL_PTK
0.7341
p.S127I
DO13863
GBM
ICGC
NEPVPGYSFSP
CBL_PTK
0.7341
p.G125C
TCGA-AP-A059
UCEC
TCGA
NEPVPGYSFSP
CBL_PTK
0.6489
p.G125C
DO41361
UCEC
ICGC
NEPVPGYSFSP
CBL_PTK
0.6489
p.E121K
TCGA-B5-A3FC
UCEC
TCGA
NEPVPGYSFSP
CBL_PTK
0.591
p.E121K
DO41871
UCEC
ICGC
NEPVPGYSFSP
CBL_PTK
0.591
p.K131R
TCGA-F5-6814
READ
TCGA
NEPVPGYSFSP
CBL_PTK
0.3056
p.K131R
DO36556
READ
ICGC
NEPVPGYSFSP
CBL_PTK
0.3056
p.E135D
DO44090
COAD
ICGC
NEPVPGYSFSP
CBL_PTK
0.1944
p.G124E
DO14228
HNSC
ICGC
NEPVPGYSFSP
CBL_PTK
0.7199
p.L121P
DO48732
LIRI
ICGC
NEPVPGYSFSP
CBL_PTK
0.7582
p.P130S
DO222868
MELA
ICGC
NEPVPGYSFSP
CBL_PTK
0.6752
p.S134P
DO232224
PBCA
ICGC
NEPVPGYSFSP
CBL_PTK
0.2222
p.Y126C
DO41758
UCEC
ICGC
NEPVPGYSFSP
CBL_PTK
0.7087
p.P130R
SIDM01112
Osteosarcoma
GDSC
NEPVPGYSFSP
CBL_PTK
0.7512
p.P130R
ACH-000748
Bone Cancer
CCLE
NEPVPGYSFSP
CBL_PTK
0.7512
p.P130R
SJSA-1
bone
COSMIC
NEPVPGYSFSP
CBL_PTK
0.7512
p.T116K
SIDM01700
Hodgkin's Lymphoma
GDSC
NEPVPGYSFSP
CBL_PTK
0.2222
p.T116K
ACH-000165
Non-Cancerous
CCLE
NEPVPGYSFSP
CBL_PTK
0.2222
p.V130A
ACH-001610
Brain Cancer
CCLE
NEPVPGYSFSP
CBL_PTK
0.6936
p.H125Y
ACH-002029
Head and Neck Cancer
CCLE
NEPVPGYSFSP
CBL_PTK
0.7229
Drug responses associated with CWF19L1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NEPVPGYSFSP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q69YN2
CWF19-like protein 1
CBL_PTK
120:130
NEPVPGYSFSP
CBL
0.5031
More...