DegronMD

Degron: NEPVPGYSFSP

Uniprot ID: Q69YN2

Source protein: CWF19-like protein 1

Source gene: CWF19L1

Class: CBL_PTK

Location: 120:130

E3 ligase: CBL

DEGRON score: 0.5031

ASA_SCORE: 60.6182

COIL: 0.8314

CONS_SCORE: 0.3192

DSS_SCORE: 0.3342

HELIX: 0.0606

FCONS_SCORE: 0.8119

RIG_SCORE: 0.7259

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L121P	DO48732	LIRI	ICGC	NEPVPGYSFSP	CBL_PTK	0.7582
p.P130R	SIDM01112	Osteosarcoma	GDSC	NEPVPGYSFSP	CBL_PTK	0.7512
p.P130R	ACH-000748	Bone Cancer	CCLE	NEPVPGYSFSP	CBL_PTK	0.7512
p.P130R	SJSA-1	bone	COSMIC	NEPVPGYSFSP	CBL_PTK	0.7512
p.S127I	TCGA-19-5956	GBM	TCGA	NEPVPGYSFSP	CBL_PTK	0.7341
p.S127I	DO13863	GBM	ICGC	NEPVPGYSFSP	CBL_PTK	0.7341
p.H125Y	ACH-002029	Head and Neck Cancer	CCLE	NEPVPGYSFSP	CBL_PTK	0.7229
p.G124E	DO14228	HNSC	ICGC	NEPVPGYSFSP	CBL_PTK	0.7199
p.Y126C	DO41758	UCEC	ICGC	NEPVPGYSFSP	CBL_PTK	0.7087
p.V130A	ACH-001610	Brain Cancer	CCLE	NEPVPGYSFSP	CBL_PTK	0.6936
p.P130S	DO222868	MELA	ICGC	NEPVPGYSFSP	CBL_PTK	0.6752
p.G125C	TCGA-AP-A059	UCEC	TCGA	NEPVPGYSFSP	CBL_PTK	0.6489
p.G125C	DO41361	UCEC	ICGC	NEPVPGYSFSP	CBL_PTK	0.6489
p.E121K	TCGA-B5-A3FC	UCEC	TCGA	NEPVPGYSFSP	CBL_PTK	0.591
p.E121K	DO41871	UCEC	ICGC	NEPVPGYSFSP	CBL_PTK	0.591
p.K131R	TCGA-F5-6814	READ	TCGA	NEPVPGYSFSP	CBL_PTK	0.3056
p.K131R	DO36556	READ	ICGC	NEPVPGYSFSP	CBL_PTK	0.3056
p.S134P	DO232224	PBCA	ICGC	NEPVPGYSFSP	CBL_PTK	0.2222
p.T116K	SIDM01700	Hodgkin's Lymphoma	GDSC	NEPVPGYSFSP	CBL_PTK	0.2222
p.T116K	ACH-000165	Non-Cancerous	CCLE	NEPVPGYSFSP	CBL_PTK	0.2222
p.E135D	DO44090	COAD	ICGC	NEPVPGYSFSP	CBL_PTK	0.1944

Showing 1 to 21 of 21 entries

Drug responses associated with CWF19L1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

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All proteins holding degron of NEPVPGYSFSP

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q69YN2	CWF19-like protein 1	CBL_PTK	120:130	NEPVPGYSFSP	CBL	0.5031	More...

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