DegronMD - Q69YU3(ANKRD34A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S327A	TCGA-50-6673	LUAD	TCGA	LRQKLSRME	DEG_APCC_DBOX_1	329:337	Mutation blocking phosphorylation signal	0.7222
p.S327A	DO24218	LUAD	ICGC	LRQKLSRME	DEG_APCC_DBOX_1	329:337	Mutation blocking phosphorylation signal	0.7222
p.P326T	TCGA-90-7766	LUSC	TCGA	LRQKLSRME	DEG_APCC_DBOX_1	329:337	Mutation rewiring degron network	0.25
p.P326T	TCGA-BQ-7048	KIRP	TCGA	LRQKLSRME	DEG_APCC_DBOX_1	329:337	Mutation rewiring degron network	0.25
p.P326T	DO20936	KIRP	ICGC	LRQKLSRME	DEG_APCC_DBOX_1	329:337	Mutation rewiring degron network	0.25
p.P326T	DO26722	LUSC	ICGC	LRQKLSRME	DEG_APCC_DBOX_1	329:337	Mutation rewiring degron network	0.25
p.P326L	TCGA-AX-A2HD	UCEC	TCGA	LRQKLSRME	DEG_APCC_DBOX_1	329:337	Mutation rewiring degron network	0.25
p.P326L	DO42608	UCEC	ICGC	LRQKLSRME	DEG_APCC_DBOX_1	329:337	Mutation rewiring degron network	0.25
p.L347I	TCGA-AY-6197	COAD	TCGA	LRQKLSRME	DEG_APCC_DBOX_1	329:337	Mutation rewiring degron network	0.0556
p.L347I	DO9956	COAD	ICGC	LRQKLSRME	DEG_APCC_DBOX_1	329:337	Mutation rewiring degron network	0.0556
p.R335P	TCGA-B0-5084	KIRC	TCGA	LRQKLSRME	DEG_APCC_DBOX_1	329:337	Mutation altering degron motif	0.6401
p.R335P	DO19713	KIRC	ICGC	LRQKLSRME	DEG_APCC_DBOX_1	329:337	Mutation altering degron motif	0.6401
p.E322K	TCGA-DX-A8BP	SARC	TCGA	LRQKLSRME	DEG_APCC_DBOX_1	329:337	Mutation rewiring degron network	0.1389
p.E322K	DO220056	SARC	ICGC	LRQKLSRME	DEG_APCC_DBOX_1	329:337	Mutation rewiring degron network	0.1389
p.P338L	TCGA-EE-A2GJ	SKCM	TCGA	LRQKLSRME	DEG_APCC_DBOX_1	329:337	Mutation rewiring degron network	0.3056
p.P338L	DO37746	SKCM	ICGC	LRQKLSRME	DEG_APCC_DBOX_1	329:337	Mutation rewiring degron network	0.3056
p.Q321H	SIDM00683	Prostate Carcinoma	GDSC	LRQKLSRME	DEG_APCC_DBOX_1	329:337	Mutation rewiring degron network	0.1111
p.Q321H	ACH-000977	lymph node	CCLE	LRQKLSRME	DEG_APCC_DBOX_1	329:337	Mutation rewiring degron network	0.1111
p.Q321H	LNCaP-Clone-FGC	prostate	COSMIC	LRQKLSRME	DEG_APCC_DBOX_1	329:337	Mutation rewiring degron network	0.1111
p.L341R	ACH-000222	Pancreatic Cancer	CCLE	LRQKLSRME	DEG_APCC_DBOX_1	329:337	Mutation rewiring degron network	0.2222
p.L341R	AsPC-1	pancreas	COSMIC	LRQKLSRME	DEG_APCC_DBOX_1	329:337	Mutation rewiring degron network	0.2222
p.T343P	ACH-001418	Ovarian Cancer	CCLE	LRQKLSRME	DEG_APCC_DBOX_1	329:337	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKRD34A

UniProt ID: Q69YU3

Entrez ID: 284615

Protein name: Ankyrin repeat domain-containing protein 34A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANKRD34A in