DegronMD

Uniprot ID: Q69YU3

Source protein: Ankyrin repeat domain-containing protein 34A

Source gene: ANKRD34A

Class: DEG_APCC_DBOX_1

Location: 329:337

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9512

ASA_SCORE: 96.0556

COIL: 0.5677

CONS_SCORE: 0.5485

DSS_SCORE: 0.7362

HELIX: 0.4089

FCONS_SCORE: 1.176

RIG_SCORE: 0.6383

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S327A	TCGA-50-6673	LUAD	TCGA	LRQKLSRME	DEG_APCC_DBOX_1	0.7222
p.S327A	DO24218	LUAD	ICGC	LRQKLSRME	DEG_APCC_DBOX_1	0.7222
p.R335P	TCGA-B0-5084	KIRC	TCGA	LRQKLSRME	DEG_APCC_DBOX_1	0.6401
p.R335P	DO19713	KIRC	ICGC	LRQKLSRME	DEG_APCC_DBOX_1	0.6401
p.P338L	TCGA-EE-A2GJ	SKCM	TCGA	LRQKLSRME	DEG_APCC_DBOX_1	0.3056
p.P338L	DO37746	SKCM	ICGC	LRQKLSRME	DEG_APCC_DBOX_1	0.3056
p.P326T	TCGA-90-7766	LUSC	TCGA	LRQKLSRME	DEG_APCC_DBOX_1	0.25
p.P326T	TCGA-BQ-7048	KIRP	TCGA	LRQKLSRME	DEG_APCC_DBOX_1	0.25
p.P326T	DO20936	KIRP	ICGC	LRQKLSRME	DEG_APCC_DBOX_1	0.25
p.P326T	DO26722	LUSC	ICGC	LRQKLSRME	DEG_APCC_DBOX_1	0.25
p.P326L	TCGA-AX-A2HD	UCEC	TCGA	LRQKLSRME	DEG_APCC_DBOX_1	0.25
p.P326L	DO42608	UCEC	ICGC	LRQKLSRME	DEG_APCC_DBOX_1	0.25
p.L341R	ACH-000222	Pancreatic Cancer	CCLE	LRQKLSRME	DEG_APCC_DBOX_1	0.2222
p.L341R	AsPC-1	pancreas	COSMIC	LRQKLSRME	DEG_APCC_DBOX_1	0.2222
p.T343P	ACH-001418	Ovarian Cancer	CCLE	LRQKLSRME	DEG_APCC_DBOX_1	0.1667
p.E322K	TCGA-DX-A8BP	SARC	TCGA	LRQKLSRME	DEG_APCC_DBOX_1	0.1389
p.E322K	DO220056	SARC	ICGC	LRQKLSRME	DEG_APCC_DBOX_1	0.1389
p.Q321H	SIDM00683	Prostate Carcinoma	GDSC	LRQKLSRME	DEG_APCC_DBOX_1	0.1111
p.Q321H	ACH-000977	lymph_node	CCLE	LRQKLSRME	DEG_APCC_DBOX_1	0.1111
p.Q321H	LNCaP-Clone-FGC	prostate	COSMIC	LRQKLSRME	DEG_APCC_DBOX_1	0.1111
p.L347I	TCGA-AY-6197	COAD	TCGA	LRQKLSRME	DEG_APCC_DBOX_1	0.0556
p.L347I	DO9956	COAD	ICGC	LRQKLSRME	DEG_APCC_DBOX_1	0.0556

Showing 1 to 22 of 22 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q69YU3	Ankyrin repeat domain-containing protein 34A	DEG_APCC_DBOX_1	329:337	LRQKLSRME	APC,CDC20,FZR1	0.9512	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons