DegronMD - Q69YZ2(TMEM200B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R204W	TCGA-A6-5661	COAD	TCGA	PRLGLPALL	DEG_APCC_DBOX_1	213:221	Mutation rewiring degron network	0.0833
p.R204W	DO8634	COAD	ICGC	PRLGLPALL	DEG_APCC_DBOX_1	213:221	Mutation rewiring degron network	0.0833
p.A211T	TCGA-F4-6570	COAD	TCGA	PRLGLPALL	DEG_APCC_DBOX_1	213:221	Mutation rewiring degron network	0.2778
p.A211T	DO10443	COAD	ICGC	PRLGLPALL	DEG_APCC_DBOX_1	213:221	Mutation rewiring degron network	0.2778
p.R214H	TCGA-HU-A4H4	STAD	TCGA	PRLGLPALL	DEG_APCC_DBOX_1	213:221	Mutation altering degron motif	0.8244
p.R214H	TCGA-L5-A8NM	ESCA	TCGA	PRLGLPALL	DEG_APCC_DBOX_1	213:221	Mutation altering degron motif	0.8244
p.R214H	DO47721	STAD	ICGC	PRLGLPALL	DEG_APCC_DBOX_1	213:221	Mutation altering degron motif	0.8244
p.L206V	TCGA-UF-A71D	HNSC	TCGA	PRLGLPALL	DEG_APCC_DBOX_1	213:221	Mutation rewiring degron network	0.1389
p.L206V	DO52109	HNSC	ICGC	PRLGLPALL	DEG_APCC_DBOX_1	213:221	Mutation rewiring degron network	0.1389
p.R207C	DO222706	COCA	ICGC	PRLGLPALL	DEG_APCC_DBOX_1	213:221	Mutation rewiring degron network	0.1667
p.R207C	SIDM00760	Small Cell Lung Carcinoma	GDSC	PRLGLPALL	DEG_APCC_DBOX_1	213:221	Mutation rewiring degron network	0.1667
p.R207C	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PRLGLPALL	DEG_APCC_DBOX_1	213:221	Mutation rewiring degron network	0.1667
p.R207H	DO233698	GACA	ICGC	PRLGLPALL	DEG_APCC_DBOX_1	213:221	Mutation rewiring degron network	0.1667
p.L220F	SIDM01117	Small Cell Lung Carcinoma	GDSC	PRLGLPALL	DEG_APCC_DBOX_1	213:221	Mutation altering degron motif	0.6981
p.L220F	ACH-002176	Lung Cancer	CCLE	PRLGLPALL	DEG_APCC_DBOX_1	213:221	Mutation altering degron motif	0.6981
p.L220F	NCI-H748	lung	COSMIC	PRLGLPALL	DEG_APCC_DBOX_1	213:221	Mutation altering degron motif	0.6981
p.P210A	SIDM01121	Small Cell Lung Carcinoma	GDSC	PRLGLPALL	DEG_APCC_DBOX_1	213:221	Mutation rewiring degron network	0.25
p.P210A	ACH-000358	Lung Cancer	CCLE	PRLGLPALL	DEG_APCC_DBOX_1	213:221	Mutation rewiring degron network	0.25
p.P210A	NCI-H69	lung	COSMIC	PRLGLPALL	DEG_APCC_DBOX_1	213:221	Mutation rewiring degron network	0.25

Kaplan plot for TMEM200B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM200B

UniProt ID: Q69YZ2

Entrez ID: 399474

Protein name: Transmembrane protein 200B (Transmembrane protein TTMA) (Two transmembrane domain-containing family member B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM200B in