DegronMD

Uniprot ID: Q69YZ2

Source protein: Transmembrane protein 200B

Source gene: TMEM200B

Class: DEG_APCC_DBOX_1

Location: 213:221

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8101

ASA_SCORE: 65.5333

COIL: 0.7332

CONS_SCORE: 0.6997

DSS_SCORE: 0.4661

HELIX: 0.2028

FCONS_SCORE: 1.0194

RIG_SCORE: 0.6975

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R204W	TCGA-A6-5661	COAD	TCGA	PRLGLPALL	DEG_APCC_DBOX_1	0.0833
p.R204W	DO8634	COAD	ICGC	PRLGLPALL	DEG_APCC_DBOX_1	0.0833
p.A211T	TCGA-F4-6570	COAD	TCGA	PRLGLPALL	DEG_APCC_DBOX_1	0.2778
p.A211T	DO10443	COAD	ICGC	PRLGLPALL	DEG_APCC_DBOX_1	0.2778
p.R214H	TCGA-HU-A4H4	STAD	TCGA	PRLGLPALL	DEG_APCC_DBOX_1	0.8244
p.R214H	TCGA-L5-A8NM	ESCA	TCGA	PRLGLPALL	DEG_APCC_DBOX_1	0.8244
p.R214H	DO47721	STAD	ICGC	PRLGLPALL	DEG_APCC_DBOX_1	0.8244
p.L206V	TCGA-UF-A71D	HNSC	TCGA	PRLGLPALL	DEG_APCC_DBOX_1	0.1389
p.L206V	DO52109	HNSC	ICGC	PRLGLPALL	DEG_APCC_DBOX_1	0.1389
p.R207C	DO222706	COCA	ICGC	PRLGLPALL	DEG_APCC_DBOX_1	0.1667
p.R207C	SIDM00760	Small Cell Lung Carcinoma	GDSC	PRLGLPALL	DEG_APCC_DBOX_1	0.1667
p.R207C	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PRLGLPALL	DEG_APCC_DBOX_1	0.1667
p.R207H	DO233698	GACA	ICGC	PRLGLPALL	DEG_APCC_DBOX_1	0.1667
p.L220F	SIDM01117	Small Cell Lung Carcinoma	GDSC	PRLGLPALL	DEG_APCC_DBOX_1	0.6981
p.L220F	ACH-002176	Lung Cancer	CCLE	PRLGLPALL	DEG_APCC_DBOX_1	0.6981
p.L220F	NCI-H748	lung	COSMIC	PRLGLPALL	DEG_APCC_DBOX_1	0.6981
p.P210A	SIDM01121	Small Cell Lung Carcinoma	GDSC	PRLGLPALL	DEG_APCC_DBOX_1	0.25
p.P210A	ACH-000358	Lung Cancer	CCLE	PRLGLPALL	DEG_APCC_DBOX_1	0.25
p.P210A	NCI-H69	lung	COSMIC	PRLGLPALL	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q69YZ2	Transmembrane protein 200B	DEG_APCC_DBOX_1	213:221	PRLGLPALL	APC,CDC20,FZR1	0.8101	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons